Efek Pemberian Ekstrak Kulit Pisang Kepok (Musa acuminata) Terhadap Jumlah Sel Spermatogonium, Spermatosit Primer Dan Sel Sertoli Mencit Jantan (Mus musculus) Yang Dipapar Asap Rokok
Daftar Isi:
- The aim of this research was investigated the effect of Musa acuminata skins extract to maintain the amount of Mus musculus spermatogonia cells, primary spermatocyte and sertoli cells which were exposed with cigarette smoke. 20 male mice aged 8-12 weeks with body weights ranging from 20-25 grams were used. These animals were divided into five groups and each group contains four mice. K- was not given any treatment, K+ was exposed with one cigarette smoke a day and then treated with aquadest. P1, P2 and P3 were exposed to one cigarette smoke a day and then treated with Musa acuminata skins extract as much as 14, 28 and 56 mg/kgBW. This research has been carried on 52 days. The data were tested by the Kolmogorov-Smirnov test and then analyzed using ANOVA (Analysis of Variants) then followed by Duncan Multiple Range test with a significance level of 5% from SPSS 20 for Windows because there were differences between treatments. The results showed that there was significant differences (P<0.05) between P1 with K- and K+, P2 with K + and P3 with K-. The conclusion of this research was dose 28 mg/kgBW of Musa acuminata skin extract can be the optimal dose to maintain the amount of Mus musculus spermatogonia cells, primary spermatocyte and sertoli cells which were exposed with cigarette smoke.