Helicobacter pylori density and expression of gastric mucosal interleukin-8 in dyspeptic patients
| Main Authors: | Hesti Ismarini, Iswan Abbas Nusi, Ummi Maimunah, Poernomo Boedi Setiawan, Herry Purbayu, Titong Sugihartono, Ulfa Kholili, Budi Widodo, Husin Thamrin, Muhammad Miftahussurur, Amie Vidyani |
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| Format: | Article PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
Yerevan State Medical University
, 2019
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/94587/1/Miftah-Helicobacter%20pylori%20density.pdf http://repository.unair.ac.id/94587/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-85073408896&partnerID=40&md5=83410a19804644647e49e393a6d7c350 |
Daftar Isi:
- Background: The density of the H. pylori colonies is associated with more severe clinical manifestations, chronic infections, ineffective therapy responses and malignant events. Interleukin-8 (IL-8) is one of cytokines that plays a role in the inflammatory process that results in gastric mucosal damage. We determined the association between H. pylori density and gastric mucosal IL-8 expression in dyspeptic patients. Methods: H. pylori density was determined using histopathology based on Updated Sydney System. IL-8 levels were measured using immunohistochemistry from the gastric biopsy. Results: There was significant difference between gastric mucosal IL-8 expression obtained in gastric mucosal gland epithelium (p = 0.028) at mild and high density of H. pylori (p = 0.013). There was a correlation between H. pylori density with gastric mucosal IL-8 expression of glandular epithelium (r = 0.622; p = 0.004), surface epithelium (r = 0.510; p = 0.026), and inflammatory cells (r = 0.054; = 0.028). Conclusion: We found a significant positive correlation between H. pylori density and gastric mucosal IL-8 expression in dyspeptic patients. © 2019, Yerevan State Medical University. All rights reserved.