Gastric Mucosa Plasma Cells is Unspecific for Diagnosing Helicobacter pylori Infection

Main Authors: Gilda Hartecia, Willy Sandhika, Ummi Maimunah, Muhammad Miftahussurur
Format: Article PeerReviewed Book
Bahasa: eng
Terbitan: The Indonesian Society of Gastroenterology, Indonesian Association for the Study of the Liver, and The Indonesian Society for Digestive Endoscopy , 2019
Subjects:
Online Access: http://repository.unair.ac.id/91880/1/24.%20gastric%20mucosa%20plasma.pdf
http://repository.unair.ac.id/91880/3/Gastric%20Mucosa%20Plasma%20cells%20is%20unspecific%20for%20Diagnosing%20Helicobacter%20pylori%20Infection.pdf
http://repository.unair.ac.id/91880/5/gastric%20mucosa.pdf
http://repository.unair.ac.id/91880/
http://www.ina-jghe.com/journal/index.php/jghe/article/view/705
https://doi.org/10.24871/202201982-86
ctrlnum 91880
fullrecord <?xml version="1.0"?> <dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><relation>http://repository.unair.ac.id/91880/</relation><title>Gastric Mucosa Plasma Cells is Unspecific for Diagnosing Helicobacter pylori Infection</title><creator>Gilda Hartecia</creator><creator>Willy Sandhika</creator><creator>Ummi Maimunah</creator><creator>Muhammad Miftahussurur</creator><subject>R Medicine (General)</subject><subject>RC Internal medicine</subject><description>Background: A high density of Helicobacter pylori is believed to trigger an accumulation of plasma cells in gastric mucosa as one of the inflammatory cells due to its high titer antibodies production circulated in blood system. We aimed to identify the correlation between total plasma cells and H. pylori density in gastric mucosa. Method: Endoscopic gastric biopsy tissues were stained by two different stains, Haematoxylin-Eosin and Modified Giemsa. The examination was performed by experienced pathologist. Results: The average age of chronic gastritis patients in this study was 48.80 years with standard deviation of 14.356. Out of 30 samples, 17 (56.7%) were female chronic gastritis patients. Female patients were dominating in most of categories of H. pylori density including 5 out of 9 patients (55.6%) in normal H. pylori density, 8 out of 14 patients (57.1%) in mild H. pylori density, and 3 out 5 patients (60.0%) in moderate H. pylori density. The average of total plasma cells in this study was 17.30 cells with standard deviation of 5.838. Importantly, there was no statistically significant correlation between total plasma cells and H. pylori density in gastric mucosa (p = 0.536). Although the distribution of total plasma cells was normal, there was no statistically significant difference of total plasma cells between positive and negative H. pylori density (p = 0.944). Conclusion: Plasma cells in gastric mucosa is unspecific for diagnosing H. pylori infection. Other causes associated with plasma cells are needed to be assessed for further study.</description><publisher>The Indonesian Society of Gastroenterology, Indonesian Association for the Study of the Liver, and The Indonesian Society for Digestive Endoscopy</publisher><date>2019-01</date><type>Journal:Article</type><type>PeerReview:PeerReviewed</type><type>Book:Book</type><language>eng</language><rights>cc_by_4</rights><identifier>http://repository.unair.ac.id/91880/1/24.%20gastric%20mucosa%20plasma.pdf</identifier><type>Book:Book</type><language>eng</language><identifier>http://repository.unair.ac.id/91880/3/Gastric%20Mucosa%20Plasma%20cells%20is%20unspecific%20for%20Diagnosing%20Helicobacter%20pylori%20Infection.pdf</identifier><type>Book:Book</type><language>eng</language><identifier>http://repository.unair.ac.id/91880/5/gastric%20mucosa.pdf</identifier><identifier> Gilda Hartecia and Willy Sandhika and Ummi Maimunah and Muhammad Miftahussurur (2019) Gastric Mucosa Plasma Cells is Unspecific for Diagnosing Helicobacter pylori Infection. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 20 (02). pp. 82-86. ISSN 2302-8181 </identifier><relation>http://www.ina-jghe.com/journal/index.php/jghe/article/view/705</relation><relation>https://doi.org/10.24871/202201982-86</relation><recordID>91880</recordID></dc>
language eng
format Journal:Article
Journal
PeerReview:PeerReviewed
PeerReview
Book:Book
Book
author Gilda Hartecia
Willy Sandhika
Ummi Maimunah
Muhammad Miftahussurur
title Gastric Mucosa Plasma Cells is Unspecific for Diagnosing Helicobacter pylori Infection
publisher The Indonesian Society of Gastroenterology, Indonesian Association for the Study of the Liver, and The Indonesian Society for Digestive Endoscopy
publishDate 2019
topic R Medicine (General)
RC Internal medicine
url http://repository.unair.ac.id/91880/1/24.%20gastric%20mucosa%20plasma.pdf
http://repository.unair.ac.id/91880/3/Gastric%20Mucosa%20Plasma%20cells%20is%20unspecific%20for%20Diagnosing%20Helicobacter%20pylori%20Infection.pdf
http://repository.unair.ac.id/91880/5/gastric%20mucosa.pdf
http://repository.unair.ac.id/91880/
http://www.ina-jghe.com/journal/index.php/jghe/article/view/705
https://doi.org/10.24871/202201982-86
contents Background: A high density of Helicobacter pylori is believed to trigger an accumulation of plasma cells in gastric mucosa as one of the inflammatory cells due to its high titer antibodies production circulated in blood system. We aimed to identify the correlation between total plasma cells and H. pylori density in gastric mucosa. Method: Endoscopic gastric biopsy tissues were stained by two different stains, Haematoxylin-Eosin and Modified Giemsa. The examination was performed by experienced pathologist. Results: The average age of chronic gastritis patients in this study was 48.80 years with standard deviation of 14.356. Out of 30 samples, 17 (56.7%) were female chronic gastritis patients. Female patients were dominating in most of categories of H. pylori density including 5 out of 9 patients (55.6%) in normal H. pylori density, 8 out of 14 patients (57.1%) in mild H. pylori density, and 3 out 5 patients (60.0%) in moderate H. pylori density. The average of total plasma cells in this study was 17.30 cells with standard deviation of 5.838. Importantly, there was no statistically significant correlation between total plasma cells and H. pylori density in gastric mucosa (p = 0.536). Although the distribution of total plasma cells was normal, there was no statistically significant difference of total plasma cells between positive and negative H. pylori density (p = 0.944). Conclusion: Plasma cells in gastric mucosa is unspecific for diagnosing H. pylori infection. Other causes associated with plasma cells are needed to be assessed for further study.
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