PENGARUH PENGEMPAAN TERHADAP STABILITAS FISIK KOKRISTAL LORATADIN-ASAM SUKSINAT 1:1 YANG DIBUAT DENGAN METODE PENGUAPAN PELARUT DAN LUMPURAN
| Main Author: | V. ERES ERFADRIN, 051511133205 |
|---|---|
| Format: | Thesis NonPeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
, 2019
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/90668/1/FF.F.37-19%20Erf%20p%20abstrak.pdf http://repository.unair.ac.id/90668/2/FF.F.37-19%20Erf%20p%20daftar%20isi.pdf http://repository.unair.ac.id/90668/3/FF.F.37-19%20Erf%20p%20daftar%20pustaka.pdf http://repository.unair.ac.id/90668/4/FF.F.37-19%20Erf%20p.pdf http://repository.unair.ac.id/90668/ http://lib.unair.ac.id |
Daftar Isi:
- Loratadine is a second generation of antihistamine H1. It belongs to biopharmaceutics classification (BCS) class 2. Loratadine has high permeability yet low solubility. Cocrystals were prepared using solvent evaporation and slurry method with molar ratio of 1:1 that has been successfully made in previous research. The objective of this study is to characterize the impact of compression to physical stability of cocrystal loratadine-succinic acid by using solvent evaporation and slurry method in some compressions force into tablet form on 10 mm diameter punch. Cocrystal after compression were characterized by Differential Thermal Analysis (DTA), Powder X Ray Diffraction (PXRD), and Scanning Electron Microscope (SEM). Tensile strength profile showed cocrystal has better mechanical property than loratadine alone. The results of the study of influence stability to physical characterization showed that cocrystal evaporation solvent and slurry method compared to loratadine, succinic acid, and its physical mixture has some differences because of the effect of compression. Thermogram of cocrystal evaporation solvent and slurry method shows the break of crystalline becomes its constituent compound because of the effect of compression. Diffractogram of cocrystal evaporation solvent and slurry method showed reduced intensity of cocrystal tablet compared to the powder on all compression force. Microphotograph of cocrystal shows different habit compared to its pure component with loss of particle boundaries of cocrystal, as sintering phenomena. This study shows that the compression caused cocrystal not physically stable.