DISOLUSI KOMPLEKS INKLUSI ASAM p-METOKSISINAMAT (APMS)- β-SIKLODEKSTRIN (β-CD) YANG DIBUAT DENGAN METODE SOLVENT DROP GRINDING
| Main Author: | YOTOMI DESIA EKA RANI, 051511133090 |
|---|---|
| Format: | Thesis NonPeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
, 2019
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/90645/1/FF.F.15-19%20Ran%20d%20abstrak.pdf http://repository.unair.ac.id/90645/2/FF.F.15-19%20Ran%20d%20daftar%20isi.pdf http://repository.unair.ac.id/90645/3/FF.F.15-19%20Ran%20d%20daftar%20pustaka.pdf http://repository.unair.ac.id/90645/4/FF.F.15-19%20Ran%20d.pdf http://repository.unair.ac.id/90645/ http://lib.unair.ac.id |
Daftar Isi:
- Para-methoxycinnamic acid (pMCA) is a major substance synthesized from Kaempferia galanga L that has an analgesic effect. It has very low solubility in water (0,71 mg/ml at 25C) which makes several boundaries in its formulation process. Therefore, to improve the solubility, pMCA was complexed with β–cyclodextrin (β-CD). Based on the diameter and depth of the cyclodextrin cavity, β-CD can form complexes with aromatic or heterocyclic compounds suitable with pMCA structure. The purpose of this study was to determine the dissolution profile of p-MCA-β-CD inclusion complex which was prepared in 1:1 molar ratio with 3 hours solvent drop grinding method. The dissolution test was prepared by apparatus 2 (paddle apparatus). The media was 500 mL aquadest pH 6,5±0,5 with 37±0,5C temperature and 75 rpm rotation speed. Concentration of pMCA was measured by visible spectrophotometer at maximum wavelength of pMCA at 285,8 nm. The inclusion complexes showed an enhancement on the dissolution profile when compared with the single compound of pMCA and the physical mixture of pMCA-β-CD prepared either by non grinding or grinding method. The result of this study showed that the Efficiency Dissolution (ED60) pMCA, non grinding and grinding physical mixture, and inclusion complex of pMCA-β-CD were 23,14±2,86; 23,19±0,70; 32,20±1,07; and 61,61±1,04 respectively. The result was statistically evaluated by one-way ANOVA analysis. It showed that the significant Pvalue was 0.000 (P-value <0,05) which means have a significant difference. It can be concluded that the inclusion complex of pMCA-β-CD increased the dissolution rate of pMCA.