Effect of Lactobacillus plantarum IS-10506 on blood lipopolysaccharide level and immune response in HIV-infected children
| Main Authors: | Alpha Fardah Athiyyah, 090970140, Herwina Brahmantya, Stephani Dwiastuti, Andy Darma, Dwiyanti Puspitasari, Dominicus Husada, 091170114, Reza Ranuh, Anang Endaryanto, 090415480 D, Ingrid Surono, Subijanto Marto Sudarmo |
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| Format: | Article PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
Teheran University of Medical Sciences
, 2019
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/85748/1/Artikel%20Effect%20of%20Lactobacillus_compressed.pdf http://repository.unair.ac.id/85748/2/Peer%20Effect%20of%20LActobacillus.pdf http://repository.unair.ac.id/85748/3/Effect%20of%20Lactobacillus%20pantarum%20IS-10506%20on%20blood%20lipopolysaccharide%20level%20and%20immune%20response%20in%20HIV-infected%20children_compressed.pdf http://repository.unair.ac.id/85748/ http://ijm.tums.ac.ir/index.php/ijm/article/view/2077 |
Daftar Isi:
- Background and Objectives: HIV enteropathy may cause disruption of the intestinal barrier, leading to a loss of CD4+ T cells, increased intestinal permeability, and microbial translocation. Lactobacillus plantarum IS-10506 has the ability to improve gut barrier function. This study investigated the effect of L. plantarum IS-10506 on a number of biomarkers of enteropathy-related damage in HIV-infected paediatric patients undergoing antiretroviral therapy (ARV). Materials and Methods: A randomized, double-blind, placebo-controlled study was conducted on 2-18 year-old children, diagnosed as HIV infected according to the WHO 2007 criteria who had received ARV for ≥ 6 months. Subjects were excluded if ARV therapy was discontinued or the patients took probiotics ≥ 2 weeks prior to the study or during the study period. Subjects were randomized into a probiotic group and placebo group. The probiotic group received L. plantarum IS-10506 2.86 × 1010 cfu/day for 6 days. Blood lipopolysaccharide (LPS) level, serum CD4+ T cell count, serum CD8+ T cell count, CD4+/CD8+ T cell ratio, and faecal sIgA level were assessed as biomarkers. Results: Twenty-one subjects completed this study. The blood LPS level decreased significantly in the probiotic group (p = 0.001). There was no significant difference in absolute CD4+ T cell count, percent CD4+ cells, absolute CD8+ T cell count, CD4+/CD8+ T cell ratio, or faecal sIgA. No serious adverse events were reported. Conclusion: The probiotic L. plantarum IS-10506 reduced the blood LPS level but showed no effect on the humoral mucosa and systemic immune response in HIV-infected children undergoing ARV therapy.