Anti Necro-inflammatory Effect of Standardized Punica granatum Extract (40% ellagic acid) on Liver Fibrosis Induced by Bile Duct Ligation in Rats
| Main Authors: | Bambang Sektiari Lukiswanto, NIDN. 0008116202, Wiwik Misaco Yuniarti |
|---|---|
| Format: | BookSection PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
Airlangga University Publishing
, 2012
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/84789/1/17.%20Anti%20Necro-Inflammatory%20Effect%20of%20.....pdf http://repository.unair.ac.id/84789/2/Peer%20Review%20Bukti%20C%2017.pdf http://repository.unair.ac.id/84789/3/Bukti%2017%20ANTI%20NECRO-INFLAMMATORY%20EFFECT%20OF%20STANDARDIZED%20PUNICA%20GRANATUM%20EXTRACT%20%2840%25%29%20ELLAGIC%20ACID%29%20ON%20LIVER%20FIBROSIS%20INDUCED%20BY%20BILE%20DUCT%20LIGATION%20IN%20RATS.pdf http://repository.unair.ac.id/84789/ |
Daftar Isi:
- The aim of this study was to evaluate the anti necro-inflammatory effect on liver fibrosis treated by standardized punica granatum extract. A total of thirty two albino rats (Rattus Norwegicus), male, Wistar strain were divided into 4 groups namely sham operated group (group I) and three main bile duct ligation groups (BDL) (group II = BDL, non-treated; group III = BDL, treated by 60 mg/kg body weight/day ellagic acid and group IV = BDL, treated by 150 mg/kg body weight/day standardized punica granatum extract respectively). The results showed a significative decrease of the necro-inflammatory score and fibrosis score for group III and group IV compared to group II but higher than group I (p < 0.05). The necroinflammatory value were higher in the group III compared to others group (p < 0.05). It can be concluded that the administration of 150 mg/kg body weight/day standardized punica granatum extract possessed hepatoprotective activity and avoided progression of fibrosis by its anti necro-inflammatory activity. Keywords: anti necroinflammatory, liver fibrosis, punica granatum extract, bile duct ligation (BDL), hepatoprotective