THE EFFECT OF PANDAN (Pandanus AmaryllifoliusRoxb.)LEAVESETHANOL EXTRACT ON HISTOPATHOLOGICALCHANGES OF ETHANOL-INDUCEDGASTRIC MUCOSAL INJURY IN MICE (Mus musculus)
| Main Author: | ALFANIA CHRISTANTI, 061411131152 |
|---|---|
| Format: | Thesis NonPeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
, 2018
|
| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/78303/1/abstrak%20kkc%20kk%20kh%20250-18%20chr%20e-min.pdf http://repository.unair.ac.id/78303/2/kkc%20kk%20kh%20250-18%20chr%20e-min.pdf http://repository.unair.ac.id/78303/ http://lib.unair.ac.id |
| ctrlnum |
78303 |
|---|---|
| fullrecord |
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><relation>http://repository.unair.ac.id/78303/</relation><title>THE EFFECT OF PANDAN (Pandanus AmaryllifoliusRoxb.)LEAVESETHANOL EXTRACT ON
HISTOPATHOLOGICALCHANGES
OF ETHANOL-INDUCEDGASTRIC
MUCOSAL INJURY IN MICE
(Mus musculus)</title><creator>ALFANIA CHRISTANTI, 061411131152</creator><subject>SF600-1100 Veterinary medicine</subject><description>This study was aimed to observe the effect of pandan (Pandanus amaryllifolius Roxb.) leaves ethanol extract on histopathological changes of ethanol-induced gastric mucosal injury in mice (Mus musculus). Twenty BALB/C mice were randomly divided into five groups. C- is negative control group which were given 0,5 ml drug solvent orally for 8 days. C+was positive control group, mice were pretreated with 0.5 ml drug solvent orally for 8 days, then on the day 8thmice were given ethanol 50% with dosage of 5ml/kg BW orally. Treatment groups were pretreated with Pandanus amaryllifolius Roxb. leaves ethanol extract with dosages of 200 mg/kg BW (T1), 400 mg/kg BW (T2) and 800 mg/kg BW (T30 for 8 days and continued with 5ml/kg BW ethanol 50% administration on day 8thexactly 1 hour after Pandanus amaryllifolius Roxb.leaves ethanol extract administration. The treatments were conducted for 7 days of acclimatization and 9 days of total treatments. At the end of the research, all mice were euthanized by cervical dislocation and gastric were collected. Gastric tissues were processed into histopathological preparation using Hematoxylin-Eosin staining. The result shows significant difference (p<0,05) between C- and C+ groups prove that ethanol 50% can cause gastric mucosal injury. Insignificant difference (P>0,05) found between C- group and treatment groups which means that Pandanus amaryllifolius Roxb. leaves ethanol extract has effect on improvement of histopathological changes of gastric mucosal injury.Dosages of 200, 400 and 800 mg/kg BW of Pandanus amaryllifolius Roxb. leaves ethanol extract have effect on reducing the epithelial damage on mucosa of mice gastric.</description><date>2018</date><type>Thesis:Thesis</type><type>PeerReview:NonPeerReviewed</type><type>Book:Book</type><language>eng</language><identifier>http://repository.unair.ac.id/78303/1/abstrak%20kkc%20kk%20kh%20250-18%20chr%20e-min.pdf</identifier><type>Book:Book</type><language>eng</language><identifier>http://repository.unair.ac.id/78303/2/kkc%20kk%20kh%20250-18%20chr%20e-min.pdf</identifier><identifier> ALFANIA CHRISTANTI, 061411131152 (2018) THE EFFECT OF PANDAN (Pandanus AmaryllifoliusRoxb.)LEAVESETHANOL EXTRACT ON HISTOPATHOLOGICALCHANGES OF ETHANOL-INDUCEDGASTRIC MUCOSAL INJURY IN MICE (Mus musculus). Skripsi thesis, Universitas Airlangga. </identifier><relation>http://lib.unair.ac.id</relation><recordID>78303</recordID></dc>
|
| language |
eng |
| format |
Thesis:Thesis Thesis PeerReview:NonPeerReviewed PeerReview Book:Book Book |
| author |
ALFANIA CHRISTANTI, 061411131152 |
| title |
THE EFFECT OF PANDAN (Pandanus AmaryllifoliusRoxb.)LEAVESETHANOL EXTRACT ON
HISTOPATHOLOGICALCHANGES
OF ETHANOL-INDUCEDGASTRIC
MUCOSAL INJURY IN MICE
(Mus musculus) |
| publishDate |
2018 |
| isbn |
061411131152 |
| topic |
SF600-1100 Veterinary medicine |
| url |
http://repository.unair.ac.id/78303/1/abstrak%20kkc%20kk%20kh%20250-18%20chr%20e-min.pdf http://repository.unair.ac.id/78303/2/kkc%20kk%20kh%20250-18%20chr%20e-min.pdf http://repository.unair.ac.id/78303/ http://lib.unair.ac.id |
| contents |
This study was aimed to observe the effect of pandan (Pandanus amaryllifolius Roxb.) leaves ethanol extract on histopathological changes of ethanol-induced gastric mucosal injury in mice (Mus musculus). Twenty BALB/C mice were randomly divided into five groups. C- is negative control group which were given 0,5 ml drug solvent orally for 8 days. C+was positive control group, mice were pretreated with 0.5 ml drug solvent orally for 8 days, then on the day 8thmice were given ethanol 50% with dosage of 5ml/kg BW orally. Treatment groups were pretreated with Pandanus amaryllifolius Roxb. leaves ethanol extract with dosages of 200 mg/kg BW (T1), 400 mg/kg BW (T2) and 800 mg/kg BW (T30 for 8 days and continued with 5ml/kg BW ethanol 50% administration on day 8thexactly 1 hour after Pandanus amaryllifolius Roxb.leaves ethanol extract administration. The treatments were conducted for 7 days of acclimatization and 9 days of total treatments. At the end of the research, all mice were euthanized by cervical dislocation and gastric were collected. Gastric tissues were processed into histopathological preparation using Hematoxylin-Eosin staining. The result shows significant difference (p<0,05) between C- and C+ groups prove that ethanol 50% can cause gastric mucosal injury. Insignificant difference (P>0,05) found between C- group and treatment groups which means that Pandanus amaryllifolius Roxb. leaves ethanol extract has effect on improvement of histopathological changes of gastric mucosal injury.Dosages of 200, 400 and 800 mg/kg BW of Pandanus amaryllifolius Roxb. leaves ethanol extract have effect on reducing the epithelial damage on mucosa of mice gastric. |
| id |
IOS3215.78303 |
| institution |
Universitas Airlangga |
| institution_id |
33 |
| institution_type |
library:university library |
| library |
Perpustakaan Universitas Airlangga |
| library_id |
468 |
| collection |
Airlangga Institutional Repositories |
| repository_id |
3215 |
| subject_area |
Adat Istiadat Administrasi Negara dan Militer Agama |
| city |
KOTA SURABAYA |
| province |
JAWA TIMUR |
| repoId |
IOS3215 |
| first_indexed |
2019-05-05T18:23:43Z |
| last_indexed |
2019-05-05T18:23:43Z |
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dc |
| _version_ |
1766060273740808192 |
| score |
17.538404 |