Identification of Physical Interaction in Binary Systems of Acyclovir–Succinic Acid
| Main Authors: | Winanta 1, Agnes Nuniek, Setyawan, Dwi, Siswandono, Siswandono |
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| Format: | Article PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
Fakultas Farmasi Universitas Airlangga
, 2016
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/75692/1/C-23%20Artikel.pdf http://repository.unair.ac.id/75692/2/C-23%20Validasi%20dan%20Peer%20Reviewer.pdf http://repository.unair.ac.id/75692/ |
Daftar Isi:
- Acyclovir, a guanosine analogue antiviral drug with low solubility of water. Due to its poorsolubility and permeability, causes low oral bioavailability.Objective:The aim of this research is toinvestigatethe physical interaction in binary systems acyclovir-succinic acid (AS).Methods:Themsystemwas prepared by solvent evaporation method.Results:Thermogram Differential Scanning Calorimetryshowed endothermic peaks at 172.68 o C(ethanol) and 171.84 o C (methanol). The Powder X-RayDiffraction (PXRD) pattern of ASwasdifferent from pure component and physical mixtures. Furthermore,physical characterization showed the binary system of AS have unique crystal habit by polarizationmicroscope.Conclusion:New crystalline phase is formed from the interaction between acyclovir andsuccinic acid by solvent evaporation methodusing ethanol and methanol.Keywords:physical interaction, acyclovir, succinic acid, binary systems