POTENSI EKSTRAK RUMPUT LAUT COKLAT (Padina australis) SEBAGAI HEPATOPROTEKTOR PADA MENCIT (Mus musculus) JANTAN YANG DIINDUKSI ALKOHOL
| Main Author: | VINTA MAULIA, 061411131026 |
|---|---|
| Format: | Thesis NonPeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/73545/1/ABSTRAK_KH.128%2018%20Mau%20p.pdf http://repository.unair.ac.id/73545/2/FULLTEXT_KH.128%2018%20Mau%20p.pdf http://repository.unair.ac.id/73545/ http://lib.unair.ac.id |
Daftar Isi:
- The purpose of this study was to know hepatoprotector potential of brown seawed (Padina australis) extract in alcohol induced mices. The research has been done on November, 20th 2017-January, 2th 2018 at Department of Veterinary Pathology, Faculty of Veterinary Medicine, Airlangga University. Twenty five male mice (Mus musculus) aged 60 days with BW 25 g were used. These animals were divided into five group (K(-), K(+), P1, P2 and P3). K(-) were treated with CMC-Na 1 % 10 ml/kgBW, K(+) were treated with alcohol 50% 12 ml/kgBW and CMC-Na 1 % 10 ml/kgBW, P1 were treated with extract of brown seawed (Padina australis) 250 ml/kgBW and alcohol 50% 12 ml/kgBW, P2 were treated with extract of brown seawed (Padina australis) 500 ml/kgBW and alcohol 50% 12 ml/kgBW and P3 were treated with extract of brown seawed (Padina australis) 1000 ml/kgBW and alcohol 50% 12 ml/kgBW. This research has been conducted for 21 days to determine the toxic effect of alcohol on the liver. The data were compared using Kruskal-Wallis test and Mann-Whitney test. Stastistical comparisons were performed using SPSS v21.0 for windows. The research result showed the potential of brown seawed (Padina australis) extract effective dose 1000 mg/kgBW could protect hepatocyte in alcohol induced mices.