Formation of Ketoprofen-Malonic Acid Cocrystal by Solvent Evaporation Method
| Main Authors: | Yudi Wicaksono, Dwi Setyawan, Siswandono |
|---|---|
| Format: | Article PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
, 2017
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/73330/1/C-9%20Artikel.pdf http://repository.unair.ac.id/73330/2/C-9%20Validasi%20dan%20Peer%20Reviewer.pdf http://repository.unair.ac.id/73330/ https://jurnal.ugm.ac.id/ijc/article/view/24884/16643 |
Daftar Isi:
- The purpose of this work was to explore the formation of ketoprofen-malonic acid cocrystal by solvent evaporation method. Early detection of cocrystal formation was conducted by hot stage microscopy and solid-liquid phase diagram. Cocrystal were prepared by solvent evaporation method by using isopropyl alcohol as solvent. Characterization of cocrystal was done by Powder X-Ray Diffractometry (PXRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared (FTIR) Spectroscopy and Scanning Electron Microscopy (SEM). The results of hot stage microscopic and solid-liquid phase diagram indicated formation of ketoprofen-malonic acid cocrystal. PXRD and DSC measurements showed stoichiometric ratio of cocrystal ketoprofen-malonic acid (2:1). The ketoprofen-malonic acid cocrystal had melting point at 86.2 °C and unique peaks of PXRD pattern at 2θ of 6.1°, 17.8°, 23.2° and 28.6°. FTIR spectra indicated the formation of cocrystal due to interaction of C=O ketone group of ketoprofen with MA molecule. SEM images show that ketoprofen-malonic acid cocrystal have multi-shaped particles with rough surfaces. Keywords: ketoprofen; cocrystal; hot stage microscopy; solid-liquid phase diagram