Solvent Concentration Effect on Powder X-Ray Diffraction And Dissolution Profiles Of Acyclovir-Nicotinamide Cocrystals
| Main Authors: | Dwi Setyawan, Siswandono, Agnes Nuniek Winantari, Kuni Zu’aimah |
|---|---|
| Format: | Article PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
, 2017
|
| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/73325/1/C-4%20Artikel.pdf http://repository.unair.ac.id/73325/2/C-4%20Validasi%20dan%20Peer%20Reviewer.pdf http://repository.unair.ac.id/73325/ |
Daftar Isi:
- Objective : Acyclovir (ACV) is well-known antiviral agent that has absorption problem, mainly due to its poor solubility in water and oral bioavailability. To improve acyclovir physical properties, especially dissolution properties, acyclovir- nicotinamide(NCT) cocrystal was formed. Methods : ACV-NCT cocrystal was prepared using slurry method using ethanol as solvent with different concentration. The ACV-NCT cocrystal from each sample groups was characterized using powder X-ray diffraction (PXRD), and then dissolution properties evaluated. Results : Each ACV-NCT cocrystals prepared from slurry method with different ethanol concentrations have different PXRD profile. Dissolution analysis (ED 15 ) showed that ACV-NCT cocrystallization using slurry methods with 10,0 ml/g as ethanol concentration significantly increase ED 15 values compared to acyclovir and acyclovir-nicotinamide physical mixture (α=0,05). Conclusion : ACV-NCT cocrystal successfully formed using slurry method with 10,0 ml/g as optimal ethanol concentration. Keywords: Cocrystal, Acyclovir, Nicotinamide, Slurry method.