Physicochemical Characterization and In Vitro Dissolution Test of Quercetin-Succinic Acid Cocrystals Prepared Using Solvent Evaporation
| Main Authors: | Setyawan, Dwi, Oktavia, Indah Puji, Farizka, Rizka, Sari, Retno |
|---|---|
| Format: | Article PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
, 2017
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/73323/1/C-2%20Artikel.pdf http://repository.unair.ac.id/73323/2/C-2%20Validasi%20dan%20Peer%20Reviewer.pdf http://repository.unair.ac.id/73323/ |
Daftar Isi:
- Objectives: Quercetin is one of the flavonoids with a polyhydroxyaromatic structure. Quercetin has been proposed to exhibit a bioWactivity against oxidative stress. However, quercetin has poor solubility in aqueous media. The purpose of this study was to investigate the physicochemical properties and dissolution rates of quercetin-succinic acid co-crystals. Materials and Methods: The quercetin-succinic acid co-crystals were prepared in 1:1 molar ratio using solvent evaporation. X-ray diffraction, differential thermal analysis, infrared spectroscopy, and scanning electron microscopy were performed to determine the physicochemical properties of quercetin-succinic acid co-crystals. Dissolution was studied in medium citrate buffer with 2% SLS for 60 min using USP II (paddle) apparatus at 100 rpm and 37°C. Results: Based on diffractogram, thermogram, infrared spectrum, and microscopic capture, the physicochemical properties of quercetin-succinic acid co-crystals showed difference to those of quercetin. In addition, the in vitro dissolution test showed that the dissolution profile of co-crystals was significantly higher than pure quercetin. Conclusion: This study suggests that the formation of quercetin-succinic acid co-crystals using solvent evaporation enhanced the physicochemical properties and dissolution rate of quercetin. Key words: Characterization, dissolution, co-crystal, quercetin, succinic acid, solvent evaporation