PENGARUH PEMBERIAN EKSTRAK AKAR PASAK BUMI Eurycomalongifolia) TERHADAP JUMLAH SEL SERTOLI DAN SEL SPERMATOGONIUM TIKUS PUTIH (Rattusnorvegicus)YANG TERPAPAR MONOSODIUM GLUTAMATE (MSG)
| Main Author: | AULIA MULIANA INSANI, 061411131066 |
|---|---|
| Format: | Thesis NonPeerReviewed Book |
| Bahasa: | ind |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/72552/1/KKC%20KK%20KH.99-18%20Ins%20p%20ABSTRAK.pdf http://repository.unair.ac.id/72552/2/KKC%20KK%20KH.99-18%20Ins%20p%20SKRIPSI.pdf http://repository.unair.ac.id/72552/ http://lib.unair.ac.id |
Daftar Isi:
- The purpose of this research was to discover the effect of Eurycoma longifolia extract towards the number of sertoli and spermatogonium cell of Rattus norvegicus which was exposed by monosodium glutamate. The research was conducted for 30 days with white male rat as experimental animal with species Rattus norvegicus. This research used complete randomized design factorial. This research used 20 white male rats which was divided into five groups of treatment, each treatment consisted of P- as negative control which was given cmc-na 2 ml and aquadest 1 ml, P+ which was given cmc-na 0,5% 1 ml and MSG 4g/kg bw/day, P1 which was given the extract of Eurycoma longifolia 600mg/kg bw/day and MSG 4g/kg bw/day, P2 which was given the extract of Eurycoma longifolia 900mg/kg bw/day and MSG 4g/kg bw/day. The result showed that the average number of sertoli cell on P-, P+, P1, and P2 was 6,440 ± 0,81731, 1,240 ± 0,08944, 2,640 ± 0,38471, 4,080 ± 0,91214 and the number of spermatogonium on P-, P+, P1, and P2 was respectively 62,760 ± 4,6376, 22,400 ±11,439, 44,320 ± 8,8324, 59,000 ± 9,2628. Based on the research result it could be concluded that the given of Eurycoma longifolia extract which was given preventively, could maintain the number of sertoli and spermatogonium cell on the testicles of rat which was exposed by MSG (p<0,05). The effective dose of Eurycoma longifolia extract that could maintain the number of sertoli and spermatogonium cell on the testicles of white male rat which was exposed by MSG was 900mg/150g bw/day.