THE PHARMACODYNAMIC PROFILE OF PROPOLIS AND PARACETAMOL ON WHITE RATS (Rattus norvegicus)
| Main Authors: | Samsuri, , I Ketut Barata, , I Made Merdana, |
|---|---|
| Other Authors: | Mochamad Lazuardi, , Rinindar, , Ietje Wientarsih, |
| Format: | BookSection NonPeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
P4IPVI
, 2018
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/70328/1/abstrak%20Oral-Edit-rev-3.pdf http://repository.unair.ac.id/70328/2/Oral-Edit-rev-3.pdf http://repository.unair.ac.id/70328/ |
Daftar Isi:
- High antioxidant found in propolis which is widely used at this time. Paracetamol has toxic effects to liver, kidney and stomach. To prevent the toxic effects of paracetamol, the provision of antioxidants which can protect cells damage caused by paracetamol is needed. This study used 25 male rats (Rattus norvegicus), which consists of five groups. Each treatment group was given standard food and drink. Group 1 (control negative) was given standard food and drink, group 2 (control positive) was given 250 mg/kg body weight of paracetamol orally, group 3 (Pp1) was given 250 mg/kg body weight of paracetamol and each rat was given 0.05 ml of propolis orally, group 4 (Pp2) was given 250 mg/kg body-weight of paracetamol and each rat was given 0.1 ml of propolis orally, and group 5 (Pp3) was given 250 mg/kg body-weight of Paracetamol and each rat was given 0.15 ml of Propolis orally. The treatments were given for 10 days, and on the 11th day, the necropsy was done to take the livers of the 25 rats for histopatology preparation. From the examination and Kruskal-Wallis test were concluded; The Paracetamol caused degeneration and necrosis with signficant defference (P < 0.01) on liver, kidney and stomach. Administration of Propolis with Paracetamol treament could prevent the degeneration and necrosis of liver, kidney and stomach with significant defference (P < 0.05).