ANALISIS PENGGUNAAN PREDNISON DOSIS TINGGI JANGKA PANJANG TERHADAP PERUBAHAN KADAR SERUM TRAP 5B PADA PASIEN ANAK SINDROM NEFROTIK SENSITIF STEROID (Penelitian dilakukan di SMF Ilmu Kesehatan Anak Divisi Nefrologi RSUD dr. Soetomo Surabaya)
| Main Author: | DESSY SURYA SETYANI, 051415153008 |
|---|---|
| Format: | Thesis NonPeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
, 2017
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/63881/1/abstrak.pdf http://repository.unair.ac.id/63881/2/TESIS%20ANALISIS%20PENGGUNAAN%20PREDNISON%20THD%20KDR%20SERUM%20TRAP%205B.pdf http://repository.unair.ac.id/63881/ |
Daftar Isi:
- Nephrotic syndrome is a condition which is characterized by protein leakage from the blood to the urine through glomeruli. It leads to hypoproteinemia and generalised oedema. Patients with nephrotic syndrome need high dose and long term glucocorticoid such as prednisone. High dose and long term glucocorticoid can increase bone resorption. Biological marker is a valuable tool to evaluate efficacy of therapy. TRAP 5B is a sensitive biological marker for bone resorption because it reflects number of osteoclasts. TRAP 5B is not affected by renal dysfunction and food. It also has a low diurnal variation than other bone resorption markers. Objectives : The aim of this study is to analyze the changes of TRAP 5B levels at induction and alternate phase in children with steroid sensitive nephotic syndrome. Method : This observational prospective research was conducted from May to October 2016. Venous blood samples obtained at 08.00-10.00 am. TRAP5B levels were measured before and after induction phase and after alternate phase using ELISA. Result : 15 patients were included in this study (60% boys). Majority of their age was 6 - <12 years and 40% were dependent steroid NS. TRAP 5B serum levels in induction phase increased by 37.41% ± 56.22%. In alternate phase, TRAP 5B serum levels increased by 28.75% ± 66.55% compare to the induction phase. However, the level change of both phase were not significant. Conclusion : TRAP 5B levels increased in induction and alternate phase after high dose and long-term prednisone treatment in nephrotic syndrome