PENINGKATAN KELARUTAN DAN LAJU DISOLUSI QUERCETIN MELALUI PEMBENTUKAN KOKRISTAL QUERCETINASAM SUKSINAT DENGAN METODE PENGUAPAN PELARUT
| Main Author: | RIZKA FARIZKA, 051211131016 |
|---|---|
| Format: | Thesis NonPeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
, 2016
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/57500/1/ABSTRACT.pdf http://repository.unair.ac.id/57500/2/FF.%20F.%2012-16%20Far%20p.pdf http://repository.unair.ac.id/57500/ http://lib.unair.ac.id |
Daftar Isi:
- Quercetin is know as a high antioxidant. And quercetin classified as Biopharmaceutical Class II (BCS II) which has poor solubility in aqueous media and high permeability. Cocrystal has been studied by many researcher as a metode to improve solubility and dissolution rate. The aim of this study is to compare the quercetine-succinic acide cocrystal (1:1, 1:2 and 1:3) solubility and dissolution rate with physical mixture (1:1, 1:2 and 1:3) and quercetin it self. The result of solubility and dissolution test were carried out to determine quercetine-succinic acid cocrystal properties. Solubility test dan dissolution test show that there is significant increase in quercetin-succinic acid cocrystal at a ratio of 1:1. And there is no significant increase in quercetin-succinic acid cocrystal at a ratio of 1:2 and 1:3.