PENGARUH SAMBUNG SILANG TERHADAP KARAKTERISTIK FISIK DAN LAJU PELEPASAN NANOPARTIKEL ARTESUNAT-KARBOKSIMETIL KITOSAN (Dibuat dengan Menggunakan CaCl2 melalui Metode Gelasi Ionik-Pengeringan Semprot)
| Main Author: | AMANI SYARAHIL, 051211132067 |
|---|---|
| Format: | Thesis NonPeerReviewed Book |
| Bahasa: | ind |
| Terbitan: |
, 2016
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/57350/1/FF.%20F.%2032-16%20Sya%20p%20abstrak.pdf http://repository.unair.ac.id/57350/19/57350.pdf http://repository.unair.ac.id/57350/3/FF.%20F.%2032-16%20Sya%20p%20lampiran.pdf http://repository.unair.ac.id/57350/ http://lib.unair.ac.id |
Daftar Isi:
- Artesunate is an anti-malarial drug that belonged to Biopharmaceutics Classification System (BCS) class II which has low bioavailability. Nanoparticle system is an effective system to improve drugs bioavailability because the particle size and surface characteristics can be easily manipulated to achieve drug target. In this study, nanoparcticle system was made by ionic gelation-spray drying method using CaCl2 as crosslinker with ratio of artesunate-carboxymethyl chitosan 2:5. Characterization of the nanoparticle system was done using SEM, DTA, FTIR, X-Ray Diffraction, drug recovery, and in vitro release was also evaluated. The result shows that nanoparticle system with polymer carboxymethyl chitosan has a rough surface and not spherical shape. However, non-crosslinked nanoparticle system has smaller particle size and more spherical shape. Based on the result of FTIR, crosslinked nanoparticle system shows sharper peaks of –OH/-NH at wavenumber 3432,11-3434,41 cm-1 that indicate the interaction between carboxymethyl chitosan and CaCl2. The result of DTA, crosslinked and non-crosslinked nanoparticle system shows sharp and different endothermic peak compared with endothermic peak of artesunate. X-Ray diffractogram of crosslinked and non-crosslinked nanoparticle system shows crystalline peak of artesunate disappear that means there is a change of crystallinity artesunate. The drug recovery of non-crosslinked nanoparticle system higher than crosslinked particulate system and significantly difference statistically. In vitro release showed that nanoparticle system have higher kinetic release than artesunate. Kinetic release of crosslinked particulate significantly difference statistically with artesunate. Keywords: artesunate, carboxymethyl chitosan, crosslinking, ionic gelation, spray drying, in vitro release