SINTESIS SENYAWA ASAM 5-METOKSI-2-(4-METILBENZOILOKSI) BENZOAT DAN UJI AKTIVITAS ANALGESIKNYA PADA MENCIT (Mus musculus)
| Main Author: | PUTRI KUSNIAWATI, 051211131044 |
|---|---|
| Format: | Thesis NonPeerReviewed Book |
| Bahasa: | ind |
| Terbitan: |
, 2016
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/56128/1/FF.%20KF.%2015-16%20Kus%20s%20abstrak.pdf http://repository.unair.ac.id/56128/2/FF.%20KF.%2015-16%20Kus%20s.pdf http://repository.unair.ac.id/56128/ http://lib.unair.ac.id |
Daftar Isi:
- Synthesis of 5-methoxy-2-(4-methylbenzoyloxy)benzoate Acid And It Anlgesic Activity Test In Mice (Mus musculus) Putri Kusniawati The perpuse of the research is to synthesis novel of derivate salycilic acid 5-metoxy-2-(4-methylbenzoyloxy)benzoate acid and it analgesic activity test in mice. 5-metoxy-2-(4-methylbenzoyloxy)benzoate acid synthesized with modification Schotten Baumann method by reacting 5-methoxy salycilic acid and 4-methylbenzoil chloride. Pyridine as catalyst and THF as solvent. The result obtained 33.65% from synthesis. After that purity test with 2 method are thin layer chromathography and melting point test. The structure confirmed by UV spectrophotometry, infrared spectrophotometry and 1H-NMR spectrometry method. It analgesic activity tested with writhing test method. And the result are ED50 of 5-methoxy-2- (4-methylbenzoyloxy)benzoate acid is 22,78 mg/kg body weight and ED50 of acetosal is 80,26 mg/kg body weight. It concluded that 5-methoxy-2-(4- methylbenzoyloxy)benzoate acid have higher analgesic activity than acetosal. Keyword: synthesis, 5-metoxy-2-(4-methylbenzoyloxy)benzoate acid, analgesic activity, ED50