PROFIL PENGGUNAAN ANTITUBERKULOSIS PADA PASIEN AIDS ANAK RAWAT INAP (Penelitian dilakukan di RSUD Dr. Saiful Anwar Malang)
| Main Author: | MAXIMA ANTONIA BOKILIA, 051211131065 |
|---|---|
| Format: | Thesis NonPeerReviewed Book |
| Bahasa: | ind |
| Terbitan: |
, 2016
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/54851/1/FF.FK.%2023-16%20Bok%20p%20abstrak.pdf http://repository.unair.ac.id/54851/2/FF.FK.%2023-16%20Bok%20p.pdf http://repository.unair.ac.id/54851/ http://lib.unair.ac.id |
Daftar Isi:
- Backgrounds: People with AIDS have an increased risk of developing various bacterial infection such as Mycobacterium tuberculosis. Children with AIDS have a better oppurtunity to TB relapse than children who are not with AIDS. The appropriate management of HIV-associated TB in children remains extremely challenging due to diagnostic difficulties, multidrug resistant, the overlapping side effect profiles of anti-TB and ARV, the complexity of drug-drug interactions and IRIS after initiation of ARV. Objective: To analyze the profile of antituberculosis drugs used in tuberculosis infection with AIDS and to identify drug related problems (DRPs) of antituberculosis drug. Method: It was a retrospective study during period January 2013 to December 2015 in children with AIDS ages 0 to 14 years receiving anti tuberculosis. Result and Discussion: Dose antituberculosis in intensive phase is FDC (R 75 mg, H 50 mg, and Z 150 mg) (1 x 1, 2, 3 and 4 tabs) po, FDC (R 37 mg, H 37 mg, Z 111 mg) 1x3⁄4 tab and FDC (R 90 mg, 60 mg H, Z 180 mg) 1x1,5 tab. Ethambutol dose is (1 x 110, 130, 200 and 400 mg) po. HES dose is H 1x145 mg, 1x360 mg E and S 1x300 mg IM. Doses intermediate phase is FDC (R 75 mg and H 50 mg. The problems that occur related to drugs is a side effect of H which causes numbness or tingling of hands and feet, RHZ cause hepatotoxicity and drug interactions of potential antituberculosis (R) and the anti-retroviral (evavirenz, nevirapine, zidovudine). Conclusion : Antituberculosis drugs use in children with AIDS were isoniazid, rifampicin, pyrazinamide, and ethambutol in combination. Route of administration of anti tuberculosis RHZE by oral and S by intramuscular. The dose in children were adjusted to the weight of patient. Keywords: Anti tuberculosis, Children with HIV, Tuberculosis