EFEK FITO PROTEKTIF EKSTRAK BATANG PISANG AMBON (Musa paradisiaca var. Sapientum) TERHADAP GAMBARAN HISTOPATOLOGI DUODENUM TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI INDOMETASIN
| Main Author: | Ardiani Dwi Pramesti, 061211133003 |
|---|---|
| Format: | Thesis NonPeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
, 2016
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/53769/1/ABSTRACT.pdf http://repository.unair.ac.id/53769/13/KH.%2065-16%20Pra%20e-ilovepdf-compressed.pdf http://repository.unair.ac.id/53769/ http://lib.unair.ac.id |
Daftar Isi:
- Indomethacin is Non-Steroidal Anti Inflammatory Drug (NSAID) such as fever, rheumathoid arthritis treatment and post surgery treatment. In this reasearch, 15 mg/kg BB indomethacin was given orally. Indomethacin has side effect on duodenum which is caused Inflammatory. The flavonoid in ethanol extract of ambon banana stem (Musa paradisiaca var.sapientum) had possibility to be used as a preventive. This research was aimed to determine the histopatology of duodenum rats. This experiment used male rats (Rattus norvegicus) aged 8-12 weeks and weigh 150 grams, were divided into five experimental groups, those were control-rats, Indomethacin induced rats, and group of ambon banana stem extract with dose of P1 = 20 mg/150gBW, P2 = 40 mg/150gBW, P3 = 80 mg/150gBW. Each duodenum specimen was processed and histopathological changes were observed. Score of epithelial integrity as qualitative data were analyzed with Kruskall Wallis test continued by Z test.The result of the study showed that ethanol extract of ambon banana stem could repaired damage of duodenum histopathology (p<0,05). Duodenum histopathology repaired was marked by improvements epithelial cells of duodenum.