Expression of FasL in Proliferation of Retinoblastoma Cells: A Mechanism Fas Counterattack
| Main Authors: | Soebagjo, Hendrian Dwikoloso, Sujuti, Hidayat, Machfoed, Hasan, Soemitro, Sutiman Bambang |
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| Format: | Article PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
Periodical Of Cukurova University Faculty Of Medicine
, 2014
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/52996/1/Karil-5%20Expression%20of%20Fasl18022017105556.pdf http://repository.unair.ac.id/52996/2/Peerreview-5%20Expression%20of%20Fasl18022017105038.pdf http://repository.unair.ac.id/52996/13/10.17826-cutf.41883-47078.pdf http://repository.unair.ac.id/52996/ http://cu.dergipark.gov.tr/download/article-file/47078 |
Daftar Isi:
- Purpose: The aim of this study were to determine the association of increasing of FasL with increasing proliferation of retinoblastoma cells. Materials and Methods: The protein expression was analyzed in 30 retinoblastoma samples from paraffin block using immunohistochemical method for evaluation of FasL, CDK4, and Ki-67 expression. Results: Among 30 retinoblastoma samples, FasL expression majority was negative in 33.3 % (10 samples) and strong in 36,8 % (11 samples). CDK4 majority 53,3% was weak expression and Ki-67 was high expression also in 53,3% (16 samples). The expression of FasL was significantly related to CDK4 (r: 0.363; p: 0.048). The CDK4 was also significantly related to Ki-67 expression (r: 0.601; p: 0.000). Conclusion: The increasing of FasL on the mechanism Fas counterattack induces proliferation of retinoblastoma cells.