Effect of Attapulgite on The Oral Bioavailability of Ciprofloxacin
| Main Authors: | Zamrotul Izzah, S.Farm., M.Sc., Apt, Veronica Gratia, , Toetik Aryani, Dra. M.Si., Apt, Suharjono, Dr., MS., Apt |
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| Format: | Article PeerReviewed Book |
| Bahasa: | ind |
| Terbitan: |
Universitas Padjadjaran
, 2013
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/52678/1/rev%20c16.pdf http://repository.unair.ac.id/52678/ https://doaj.org/article/e60e48d9a39a445486b68005ae744b91 |
Daftar Isi:
- This study was aimed to determine the effect of attapulgite on the bioavailability of a single orallyadministered ciprofloxacin. Six New Zealand white rabbits received each of the following treatments in a randomized, three-way crossover sequence, separated by a 7-day washout period: (i) ciprofloxacin (23 mg/kgBW) alone; (ii) ciprofloxacin (23 mg/kgBW) given simultaneously with attapulgite (28 mg/ kgBW); (iii) ciprofloxacin (23 mg/kgBW) given 2 hours after attapulgite (28 mg/kgBW). Blood samples (1 mL) were collected from the marginal ear vein up to 240 minutes postdose. The plasma concentrations of ciprofloxacin were determined by a validated high-performance liquid chromatography method. The maximum concentration and oral bioavailability (AUC0-240 min) of ciprofloxacin were significantly decreased by 49 % and 32 % when administered concomitantly with attapulgite (p < 0.001). Attapulgite appeared to have no significant effect on the bioavailability of ciprofloxacin when administered 2 hours before ciprofloxacin. In conclusion, the oral bioavailability of ciprofloxacin was markedly reduced when administered concomitantly with attapulgite. This drug-drug interaction may decrease clinical efficacy and promote microbial resistance to ciprofloxacin. However, the interaction could be minimized by separating the adminsitration of these drugs at least 2 hours