PERBANDINGAN HASIL SCHIRMER-I PASCA PEMBERIAN TIMOLOL 0.5% DENGAN DAN TANPA PRESERVATIVE BENZALKONIUM CHLORIDE 0,01% (Studi Eksperimental pada Oryctolagus cuniculus)
| Main Author: | REZEKIAN, 011080113 |
|---|---|
| Format: | Thesis NonPeerReviewed Book |
| Bahasa: | ind |
| Terbitan: |
, 2016
|
| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/39959/1/8.%20ABSTRAK.pdf http://repository.unair.ac.id/39959/2/PPDS.IKM.03-16%20Rez%20p.pdf http://repository.unair.ac.id/39959/ http://lib.unair.ac.id |
Daftar Isi:
- Objective : To study the comparison of Schirmer-I result after instillation of 0,5% timolol with and without preservative for two weeks on New Zealand white rabbit (Oryctolagus cuniculus). Methods : This an experimental study on twenty healthy New Zealand male rabbits (Oryctolagus cuniculus), weighing between 2.5 to 3.5 kg, to 2 groups. Ten rabbits was given 0.5 % timolol eyedrop with Benzalkonium chlorida (BAC) 0.01% as preservative and ten rabbits was given 0.5% timolol without preservative for two weeks. Schirmer-I result was done on day 0, 3rd, 5th, 7th, and 14th. Result : There was significant decrease of Schirmer-I result in both groups from day 3, day 5, day 7, and day 14 (p = 0.000). However the preservative group showed a significantly larger decrease in Schirmer-I compare to non preservative group. Significant difference was found on Schirmer I on day 3 (p=0.013), day 5 (p=0.002), day 7 (p=0.000) between preservative and non preservative groups. Conclusions : This study shows a difference in Schirmer-I result between the preservative group (0.5% timolol with preservative agent Benzalkonium chlorida (BAC) 0.01%) and non preservative group. Timolol itself can decrease Schirmer-I test result, but the additional preservative showed more significant decrease in Schirmer-I.