Serologic and Molecular Characteristics of Hepatitis B Virus among School Children in East Java, Indonesia
| Main Authors: | Takako Utsumi, Yoshihiko Yano, Maria Lucia Inge Lusida, Mochammad Amin, Soetjipto, Hak Hotta, Yoshitake Hayashi |
|---|---|
| Format: | Article PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
American Society of Tropical Medicine and Hygiene
, 2010
|
| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/100176/1/Serologic%20and%20molecular.pdf http://repository.unair.ac.id/100176/2/Serologic%20and%20Molecular.pdf http://repository.unair.ac.id/100176/3/Serologic%20and%20Molecular%20Characteristics%20Of%20Hepatitis%20B%20virus%20among%20school%20children%20in%20east%20java%2C%20indonesia.pdf http://repository.unair.ac.id/100176/ https://www.ajtmh.org/content/journals/10.4269/ajtmh.2010.09-0589 https://doi.org/10.4269/ajtmh.2010.09-0589 |
Daftar Isi:
- Universal childhood hepatitis B vaccination was introduced in Indonesia in 1997; by 2008, coverage was estimated to be 78%. This study aimed to investigate the serologic status and virologic characteristics of hepatitis B virus (HBV) among the children in East Java. A total of 229 healthy children born during 1994–1999 were enrolled in this study. Overall, 3.1% were positive for hepatitis B surface antigen (HBsAg) and 23.6% were positive for antibody to HBsAg (anti-HBs). HBV DNA was detected in 5 of 222 HBsAg-negative carriers, which were suggested to be cases of occult HBV infection. A single amino substitution (T126I) in the S region was frequently found. HBV infection remains endemic, and the prevalence of anti-HBs remains insufficient among children in East Java, Indonesia.