RED DRAGON FRUIT (Hylocereus Polyrhizus) EXTRACT DECREASED LACTIC ACID LEVELAND CREATINE KINASE ACTIVITY IN RATS RECEIVING HEAVY PHYSICAL EXERCISE
| Main Authors: | Harahap, Novita Sari, Amelia, Rina |
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| Format: | Article PeerReviewed Book |
| Bahasa: | ind |
| Terbitan: |
Scientific Foundation SPIROSKI
, 2019
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| Subjects: | |
| Online Access: |
http://digilib.unimed.ac.id/42649/1/Reviewer.pdf http://digilib.unimed.ac.id/42649/2/Turnitin.pdf http://digilib.unimed.ac.id/42649/3/Submit%20Accepted.pdf http://digilib.unimed.ac.id/42649/ https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.626 |
Daftar Isi:
- BACKGROUND: Heavy physical exercise causes relative hypoxia. In hypoxic condition, the cellâ€TMs energy comes from anaerobic metabolism that produces lactic acid. An increment of oxygen need leads to ischemia-reperfusion, triggers free radical formation and damages muscles. Creatine kinase (CK) is a marker of muscle tissue damage. Red dragon fruit (RDF) has potential as antioxidant to reduce free radical formation. AIM: This study aims to determine RDF extract potential to reduce the lactic acid level and CK activity after heavy physical exercise. METHODS: A total of 32 male rats (Rattus Norvegicus) were randomly divided into 4 groups: group NORDF, treated heavy physical exercise and distilled water; group RDF100, treated heavy physical exercise and at 100 mg/kg BW RDF extract; group RDF200, treated heavy physical exercise and at 200 mg/kg BW RDF extract and group RDF300, treated heavy physical exercise and at 300 mg/kg BW RDF extract. The rats swam for 20 minutes, 3 times a week for 3 weeks. RESULTS: RDF300 group showed lower lactic acid level and CK activity as compared to that of NORDF (p = 0.00) and RDF100 (p = 0.00) groups, but RDF300 are not significantly different for lactic acid (p = 0.45) and for CK (p = 0.68). CONCLUSION: Red dragon fruit extract has potential in lowering lactic acid level and CK activity in male rats receiving heavy physical exercise.