Analgesic Activity of Papaya Leaf Extract (Carica papaya L.) on Male Mice induced by Acetic Acid 1%
| Main Authors: | Afrianti, Ria, Yenti, Revi, Meustika, Dewi |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | ind |
| Terbitan: |
Fakultas Farmasi Universitas Andalas
, 2015
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| Subjects: | |
| Online Access: |
http://jsfk.ffarmasi.unand.ac.id/index.php/jsfk/article/view/12 http://jsfk.ffarmasi.unand.ac.id/index.php/jsfk/article/view/12/8 |
Daftar Isi:
- Analgesic activity of extract of papaya leaves (Carica papaya L.) to male mice has been evaluated. Twenty five of mice (20-30 g, 2-3 months old) were divided randomly into five groups. The first group was given sodium CMC as negative control, the second until fourth groups received ethanolic extract of Carica papaya leaves in the doses of 100, 300, and 600 mg/kgBW, respectively and the fifth group was given paracetamol 65 mg/kg BW. All interventions were administered as single dose by oral route on given day. Acetic acid 1% (w/v) was used as the pain inductor. Analgesic activity was measured by counting the percentage of writhing movements as a measure of the analgesic effect produced by each intervention. Data were analyzed with one way ANOVA to compare analgesic activity between treatment groups. The results showed that the analgesic effect of the extract on the doses of 100, 300, and 600 mg/kg BW was significantly different with control group (P
- Evaluasi aktivitas analgesia dari ekstrak etanol daun pepaya (Carica papaya L.) pada mencit putih jantan telah dilakukan. Dua puluh lima ekor mencit (20-30 g, 2-3 bulan) dibagi secara acak menjadi lima kelompok. Grup pertama diberi NaCMC sebagai kontrol negatif, sedangkan kelompok 2-4 menerima ekstrak etanol daun Carica papaya dengan dosis 100, 300, dan 600 mg/kgBB dan kelompok kelima diberi parasetamol 65 mg/kgBB sebagai pembanding. Semua intervensi diberikan sebagai dosis tunggal secara oral. Asam asetat 1% (b/v) digunakan sebagai penginduksi nyeri. Aktivitas analgesik diukur dengan menghitung persentase geliatan sebagai ukuran efek analgesik yang dihasilkan oleh setiap intervensi. Data dianalisis dengan ANOVA satu arah untuk membandingkan aktivitas analgesik antara kelompok perlakuan. Hasil penelitian menunjukkan ekstrak pada dosis 100, 300, dan 600 mg/kgBB memberikan efek yang berbeda nyata dibandingkan dengan kontrol (P