Malaria Species And Southeast Asian Ovalocytosis Defined By A 27-BP Deletion In The Erythrocyte Band 3 Gene
| Main Authors: | Kimura, Masako, Soemantri, Augustinus , Ishida, Takafumi |
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| Format: | Article PeerReviewed application/pdf |
| Terbitan: |
, 2002
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| Subjects: | |
| Online Access: |
http://eprints.undip.ac.id/555/1/02-2760.pdf http://www.tm.mahidol.ac.th/seameo/2002_33_1/02-2760.pdf http://eprints.undip.ac.id/555/ |
Daftar Isi:
- To evaluate the resistance of SAO against species specific malaria infection, relationships between parasite species and the 27-bp deletion in the band 3 gene were studied in malaria endemic Sumba Island, eastern Indonesia. Thick blood films were prepared from patients with malaria symptoms (n=129) and healthy controls (n=231). Species of Plasmodium was identified by microscopic observation. The 27-bp deletion was screened by the PCR method. Among 231 healthy controls, 29 (12.6%) had the 27-bp deletion, whereas 14 (10.9%) among 129 patients confirmed with malaria infection harbored the 27-bp deletion. No significant difference was observed in the prevalence of the 27-bp deletion between controls and patients (p>0.8). There was no significant difference in the frequency of the 27-bp deletion between P. vivax and P. falciparum infected subjects at 5% level by Fisher’s exact test. The present result showing no correlation between the presence of the 27-bp deletion and infected parasite species is consistent with the post-invasion resistance hypothesis that may involve not a single malaria species.