Fluoroquinolone-resistant Escherichia coli, Indonesia
| Main Authors: | Kuntaman, Kuntaman, Lestari, Endang Sri, Severin, Juliëtte A., Kershof, Irma M., Mertaniasih, Ni Made, Purwanta, Marijam, Hadi, Usman , Johnson, James R. , Belkum, Alex van , Verbrugh, Henri A. |
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| Format: | Article PeerReviewed application/pdf |
| Terbitan: |
Department of Medical Microbiology and Infectious Diseases
, 2005
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| Subjects: | |
| Online Access: |
http://eprints.undip.ac.id/3256/1/cdc04-1207.pdf http://www.cdc.gov http://eprints.undip.ac.id/3256/ |
Daftar Isi:
- In a recent, population-based survey of 3,996 persons in Indonesia, fluoroquinolone (FQ)-resistant Escherichia coli was prevalent in the fecal flora of 6% of patients at hospital admission and 23% of patients at discharge, but not among healthy relatives or patients visiting primary healthcare centers (2%). Molecular typing showed extensive genetic diversity with only limited clonality among isolates. This finding suggests that independent selection of resistant mutants occurs frequently. FQ-resistant isolates exhibited a higher rate of spontaneous mutation, but sparser virulence profiles, than FQ-susceptible isolates from the same population. The resistant isolates belonged predominantly to phylogenetic groups A (57%) and B1 (22%) but also to the moderately virulent group D (20%). Hypervirulent strains from the B2 cluster were underrepresented (1%). Because FQ-resistant E. coli can cause disease, especially nosocomial infections in immunocompromised patients, spread of such strains must be stopped.