Extraction of Diterpenoid Lactones of Andrographis paniculata using Liquid Solvents: Effect of Solvent’s Hildebrand Solubility Parameter on Extraction Efficiency
| Main Authors: | Kumoro, A.C., Hasan, M. |
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| Format: | Proceeding PeerReviewed application/pdf |
| Terbitan: |
, 2006
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| Subjects: | |
| Online Access: |
http://eprints.undip.ac.id/267/1/ANDR_I_TECHPOS.pdf http://eprints.undip.ac.id/267/ |
Daftar Isi:
- Two diterpenoid lactones responsible to the multi healing properties of Andrographis paniculata have been extracted using 16 different liquid solvents. The effect of Hildebrand solubility parameter of the solvents on solid-liquid extraction yield using standard soxhlet extraction method was investigated. The Hildebrand solubility parameter concept performed well when predicting lower polar solvent effect on extraction efficiency. However, ethanol extracted less andrographolide than methanol even though ethanol has closer Hildebrand solubility parameter value to andrographolide compared to that of methanol. Methanol’s shorter aliphatic chain and higher polarity, which lead to easier hydroxyl group liberation, seemed to contribute this discrepancy.