EFFECT OF SOLVENT FLOW RATE ON THE SUPERCRITICAL CARBON DIOXIDE EXTRACTION OF ANDROGRAPHOLIDE FROM ANDROGRAPHIS PANICULATA
| Main Authors: | Kumoro, A.C., Hasan, M. |
|---|---|
| Format: | Proceeding PeerReviewed application/pdf |
| Terbitan: |
, 2006
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| Subjects: | |
| Online Access: |
http://eprints.undip.ac.id/244/1/Masitah11thAPCCHe_Manuscript.pdf http://eprints.undip.ac.id/244/ |
Daftar Isi:
- Malaysia is one of the major medicinal plants (Andrographis paniculata) producers in the world. Extraction of bioactive component (andrographolide) from ground dried leaves of this plant using supercritical carbon dioxide has been studied. The effect of solvent flow rates ranging from 7.95 × 10-6 to 6.36 × 10-5 kg/s on the extraction efficiency has been investigated. The extraction yield increased with the increase of solvent flow rate from 7.95 × 10-6 to 3.18 × 10-5 kg/s. However further increase of solvent flow rate reduced the extraction yield. Therefore, an optimum solvent flow rate at 3.18 × 10-5 kg/s was obtained for the system under study. The extraction process was found to be controlled by intraparticle diffusion of the andrographolide in the starting leaves particles.