Effects of BCG Vaccination Prior to Specific Immunotherapy on IL-4/IFN-Î3 Ratio and AR Total Symptom Score in Persistent Allergic Rhinitis (Efek vaksinasi BCG pre imunoterapi spesifik terhadap rasio IL-4/IFN-Î3 dan skor gejala total rinitis pada rinitis alergi persisten)
| Main Author: | Suprihati , Suprihati |
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| Format: | Article PeerReviewed application/pdf |
| Terbitan: |
Fakultas Kedokteran Universitas Diponegoro
, 2009
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| Subjects: | |
| Online Access: |
http://eprints.undip.ac.id/19099/1/05_suprihati_-__effects_of_BCG_vaccination.pdf http://www.mediamedika.net http://eprints.undip.ac.id/19099/ |
Daftar Isi:
- Background: Allergic disease including allergic rhinitis (AR) is dominated by Th2 responses with increased production of IL-4 and inhibition of IFN-ï§ production. BCG vaccination induced IL-12 production which promotes Th0 to Th1 shift and stimulates IFN-ï§ production. The aim of this study is to determine whether BCG vaccination prior specific immunotherapy (SIT) could increase initial phase of SIT responses measured by decreasing IL-4/IFN-ï§ ratioâs and AR total symptom score (TSS). Method: This study was carried out by a randomized controlled trial. A total of 84 patients with moderate to severe persistent AR were randomized and assigned into 4 treatment groups (BCG solvent, BCG vaccination, SIT, and BCG vaccination prior SIT). A subcutaneous SIT was given using mixed house dust mite extract (D pteronyssinus and D farinae, 50/50), while BCG vaccination was given by intracutaneous injection. Clinical symptoms and concentrations of IL-4 and IFN-Î3 were measured by PHA stimulated fresh whole blood culture, before and after 8 weeks of SIT. Result: There were no significance difference between the concentrations of IL-4 and IFN-Î3, and their ratio in all four groups. However, there is a significant lower IL-4/IFN-ï§ ratio in the group with pretreatment of BCG than SIT (p=0.024), while during the initial phase, AR symptoms in patients who received BCG prior SIT is significantly lower than SIT (p=0.027). Conclusion: This study demonstrates that BCG vaccination prior to SIT treatment could increase initial phase of SIT responses in persistent allergic rhinitis without additional adverse effects.