The Role of Cytokines in Activation of Coagulation and Fibrinolysis in Dengue Shock Syndrome
| Main Authors: | Suharti, Catharina, Gorp , Eric C.M. van, Setiati , Tatty E. , Dolmans, Wil M.V., Djokomoeljanto, Robert J. , Hack, C. Erik, Cate, Hugo ten , Meer, Jos W.M. van der |
|---|---|
| Format: | Article PeerReviewed application/pdf |
| Terbitan: |
Ikatan Dokter Anak Indonesia
, 2002
|
| Subjects: | |
| Online Access: |
http://eprints.undip.ac.id/1633/1/The_Role_of_Cytokines_in_Activation_of_Coagulation_and_Fibrinolysis_in_Dengue_Shock_Syndrome.pdf http://pediatrics-undip.com http://eprints.undip.ac.id/1633/ |
Daftar Isi:
- In a prospective clinical study of 50 patients with Dengue Shock Syndrome (DSS), we investigated the association of tumor necrosis factor- (TNF-), interleukin-1 (IL-1), IL-1 receptor antagonist (IL-1Ra), and IL-6 with activation markers of coagulation (F1+2 and TATc) and fibrinolysis (t-PA, PAPc, and D-dimer). We found that TNF-, IL-1 and Il-1Ra, but not IL-6, concentrations were elevated in the circulation during the early stage of infection and at discharge from hospital. TNF- was significantly associated with D-dimer, an activation marker of fibrinolysis (p < 0.003), but not with activation markers of coagulation. IL-1 was significantly associated with t-PA (p < 0.03). IL-1Ra was significantly associated with F1+2, TATc (p < 0.04 and p < 0.02, respectively), whereas IL-6 was significantly associated with both, activation markers of coagulation (F1+2; p < 0.03) and fibrinolysis (PAPc; p = 0.002). Our data are in line with studies in bacterial sepsis. In severe dengue virus infection the same cytokines are involved in the onset and regulation of hemostasis.