PERBANDINGAN DAYA GUNA OBAT KETAMIN KUMUR 40 MG DAN BENZYDAMINE HCL 0,075 % UNTUK MENGURANGI NYERI TENGGOROK POST INTUBASI

Main Authors: , dr, Bambang Eko Subekti, , Dr. Muhdar Abubakar, Sp.An(K), KIC.
Format: Thesis NonPeerReviewed
Terbitan: [Yogyakarta] : Universitas Gadjah Mada , 2012
Subjects:
ETD
Online Access: https://repository.ugm.ac.id/99961/
http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=56107
Daftar Isi:
  • Background : Sore throat is a frequent complication in postoperative patients under general anesthesia which performed with intubation endotracheal tube. This effect occurs because of irritation, mucosal damage and inflammation of the airways due to gel as lubricant, laryngoscopy or because of the emphasis of the endotracheal tube cuff. Objective : Compare between the efficacy of 40 mg ketamine gargle and 0.075% benzydamine HCL gargle prior installation of endotracheal tube to reduce post intubation sore throat. Methods : Double-blind randomized controlled trial. Subjects were patients with aged 18-50 years and with physical status of ASA I and II who underwent an elective surgery with general anesthesia in Sardjito Hospitalâ��s operating theater. Subjects were divided into 2 groups, 50 patients of A group given 30 ml ketamine gargle 40 mg and 51 patients of B group given 15 ml benzydamine HCL gargle 0,15% added water to 30 ml volume. The sore throat was measured after the patient were fully awake, 2 hours and 4 hours postoperative with Canbay score: no pain, mild pain, moderate pain and severe pain. Data analysis used t-test and chi-square with 95% CI and significant if p<0.05. Result : There was a significant difference (p<0.01) in sore throat incedence during both groups especially at fully awake and 2 hours post extubation, 20% in A group versus 66.7% in B group at fully awake and 16% in A group versus 58,8% in B group at 2 hours of post extubation. There was no significant difference in sore throat incidence during both groups at 4 hours post extubation (p=0.394). Conclusion : Ketamine gargle 40 mg given 5 minutes before intubation is more efficient in reducing sore throat after general anesthesia with endotracheal tube compared with benzydarnine HCL 0.075% at fully awake and 2 hours post-extubation.