Perubahan Ukuran Droplet Propofol 1% sebelum dan setelah Prosedur Penyimpanan selama 6 dan 24 Jam
| Main Authors: | , Basuki Rahmat, , dr. Bambang Suryono S., M.Kes., SpAn., KIC, KNA |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2012
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/99569/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=56032 |
Daftar Isi:
- Background. Propofol (2,6-diisopropylphenol) has gained popularity as an anesthetic agent both for induction and maintenance of anesthesia. Propofol is formulated as a lipid macroemulsion containing soybean oil (100 mg/ml), lecithin (12 mg/ml), and glycerol (22,5 mg/ml). This macroemulsion of propofol is thermodynamically unstable and degrades over time by enlargment of the droplet size. Degradation is faster if the propofol emulsion has been open from the package (ampoule). Enlargement of droplet size of propofol resulted in decreased release rate of propofol, and decrease propofol concentrations. The risk of embolism occurs when the droplet size exceeds the limit required by the FDA which are the mean droplet size (MDS) <0.45 Î1⁄4m and the percentage of fat globule population >5 Î1⁄4m (PFAT5 ) <0.05%. In the daily practice we often find the use of propofol emulsions that have been opened from packaging (ampoule) and saved more than 24 hours. The purpose of this study was to know the droplet size changed of propofol before and after the procedure storage for 6 and 24 hours. Methods. The design of study is a cohort prospective study to know the droplet size changed of propofol before and after the procedure storage for 6 and 24 hours with 16 samples propofol. Droplet size was observed under the electron microscope. Data was analysed and tested with ANOVA, followed by Tukeyâ��s Post Hoc method to analyze MDS differences between baseline and each time interval. p value of <0.05 was considered statistically significant. Results. MDS has been changed from time to time. At the 0 time (baseline) the MDS was 225 ± 24.2 nm, at the 6th hour was 247 ± 22 nm and at the 24th hour was 278 ± 28.8 nm. The MDS changed over time was statistically significant (p <0.05). The PFAT5 values each time interval were 0%. There were no colour and homogenity changed between each time interval (n=16/100% each time interval). Conclusion. The droplet size of propofol have been changed before and after the storage procedures for 6 and 24 hours in refrigerator with temperature 4ÂoC, it was 225 ± 24.2 nm at the 0 time (baseline), becoming 247 ± 22 nm at the 6th hour and 278 ± 28.8 nm at the 24th hour. The MDS changed over time was statistically significant (p <0.05).