SINTESIS RESIN POLI-KALIKS[4]ARENA DARI p-t-BUTILFENOL DAN PEMANFAATANNYA SEBAGAI ADSORBEN SERTA ANTIDOTUM KERACUNAN LOGAM BERAT
| Main Authors: | , TRIANA KUSUMANINGSIH, , Prof. Drs. Jumina, Ph.D. |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2012
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/99343/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=54814 |
Daftar Isi:
- Synthesis of poly-calix[4]arene resins and their applications as adsorbent as well as antidote for heavy metal poisoning had been conducted. The synthesis of poly-calix[4]arenes from 25,26,27,28-tetraallyloxycalix[4]arene, tetra-pallylcalix[ 4]arene, tetra-p-allylcalix[4]arene tetra acetic ester and tetra-pallylcalix[ 4]arene tetra acetic acid were performed via crosslink reaction in the presence of concentrated sulfuric acid. Calix[4]arenes were synthesized using p-tbutylphenol as a starting material. Structure identifications were carried out by means of FTIR and 1H-NMR spectrometers. Further characterizations of the resins included surface morphology, surface area analysis, size and pores distribution using SEM and SAA. The synthesized resins were applied as adsorbent for Cr(III), Pb(II), Ag(I) and Cd(II) heavy metal cations. The adsorption study was conducted in batch system by investigating the effects of acidity (pH), contact time and initial concentration of heavy metal. In their application as antidote, adsorption of essential minerals of Ca, Fe and Zn, determination of partition coefficient, tests of acute toxicity as well as antidote activity on Cd poisoning were also studied. In general, the adsorption of heavy metal on the resins had the optimum pH in region of 4â��6 and reached the equilibrium condition in 40 minutes. The adsorption processes followed second order adsorption kinetic model of Ho, where the R2 for every interaction of adsorbent-adsorbate varied from 0.9103 to 0.9998. The adsorption of cations on the resins tended to follow the Langmuir isothermal pattern. The highest adsorption capacity was obtained from the interaction between poly-tetra-p-allylcalix[4]arene and Cr(III), 345.0 Î1⁄4mol/g (17.92 mg/g), whereas the lowest capacity belonged to that of poly-tetra-pallylcalix[ 4]arene and Pb(II), 32.3 Î1⁄4mol/g (6.69 mg/g). Based on the in vitro study of the essential metal adsorption, it could be concluded that the utilization of poly-25,26,27,28-tetraallyloxycalix[4]arene resin as antidote in Cd poisoning had to be coupled with the provision of supplement containing Fe and Zn. Partition coefficient of poly-25,26,27,28- tetraallyloxycalix[4]arene at pH 3.5 and 7.4 were 0.80±0.05 and â��0.22±0.05, respectively. Acute toxicity test of poly-25,26,27,28-tetraallyloxycalix[4]arene as single oral dose on white mice (strain of BALB/c), male and female showed that the LD50 was higher than 260 mg/kg BW. The antidote activity test at the same concentration with dimercaprol (0.65 mg/kg BW) as standard antidote showed that the resin displayed better activity in decreasing Cd concentration in kidney, liver and blood which were 73.95%, 84.27%, and 87.83%, respectively and 66.21%, 70.71%, and 49.74%, respectively for dimercaprol.