HUBUNGAN HIPERTIROID OVERT DAN HIPERTIROID SUBKLINIS DENGAN GANGGUAN KOGNITIF DI RSUP DR SARDJITO YOGYAKARTA
| Main Authors: | , Berkat Hia, , dr. Pernodjo Dahlan, SpS(K) |
|---|---|
| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2012
|
| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/99061/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=54878 |
Daftar Isi:
- Hyperthyroidism is a metabolic imbalance resulting from excessive production of thyroid hormones. Overt or subclinical hyperthyroid prevalence has reached 20%. Differences in thyroid status induces apoptosis in adult cerebral cortex. Triiodothyroxine (T3) acts directly on the cerebral cortex mitochondria and induces release of cytochrome c to induce apoptosis. Increased hormone levels encountered in hyperthyroidism associated with an increase in necrotic death of neurons and oxidative stress has a negative effect on cognition. Several studies linking hyperthyroidism with cognitive impairment showed a significant, but controversial results. This study is a cross-sectional study involving 68 patients with hyperthyroidism, who were treated in endocrine polyclinic of RSUP Dr. Sardjito hospital Yogyakarta. The inclusion criteria were hyperthyroidism based on anamnesis, clinical examination and laboratory tests, age of 20-60 years, symptoms of hyperthyroidism or hyperthyroidism, minimum education of elementary education. The relationship of hyperthyroidism and cognitive impairment was tested by Chi- Square test and logistic regression tests for multivariate analysis. The results were statistically significant if the value of p is <0.05. Totally there were 68 subjects included in the study. The analysis results showed that overt hyperthyroidism was significant for cognitive impairment (p = 0.021). Other variables associated with cognitive impairment were female gender (p = 0.019). In a multivariate analysis of the variables of overt hyperthyroidism (p = 0.024) and gender (p = 0.025) had independent association with cognitive impairment. Conclusion This study found that overt hyperthyroidism had a significant association with incidence of cognitive impairment compared to subclinical hyperthyroidism