PERBANDINGAN WAKTU OPTIMAL PEMBERIAN FENTANYL 1,5 Î1⁄4g/kgBB UNTUK MENGURANGI RESPON HEMODINAMIK PADA INTUBASI ENDOTRAKHE
| Main Authors: | , GUNTUR MUHAMMAD TAQWIN, , Dr. I Gusti Ngurah Rai Artika, SpAn.K, |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2011
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/91131/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=53738 |
Daftar Isi:
- Laryngoscopy and endotracheal intubation are procedures commonly conducted in general anesthesia, but the action of laryngoscopic endotracheal intubation often lead to reflex of increased activity both symphatic and sympathoadrenal. Some drugs have been used to minimize these responses, such as administration of local anesthetic agents, beta blocker, alfa 2 blocker and vasodilators. Fentanyl is one of anesthetic agents that is widely used to decrease cardiovascular responses. To obtain optimum result from fentanyl, both technique and duration of administration of fentanyl before intubation, should be determined. This research aimed to compare the time of administration of fentanyl before endotracheal intubation response (1.5 Âμg/kgbw in minute 2, minute 5 and minute 7) to hemodynamics which occurs as blood pressure, mean arterial pressure amd rate pressure product This research employed an observational design with cohort study, with number of subjects of 51 patients, physical status ASA I and II who were planned to underwent elective surgery with general anesthesia in Dr. Sardjito General Hospital, Yogyakarta. Subjects were then divided to three groups, each consisted of 17 subjects. Group A was provided with intravenous fentanyl 1.5 Âμg/kgbw which was given 2 minutes before laryngoscopic intubation, group B was provided with intravenous fentanyl 1.5 Âμg/kgbb which was given 5 minutes before laryngoscopic intubation, and group C was provided with intravenous fentanyl 1.5 Âμg/kgbw which was given 7 minutes before aryngoscopic intubation. Measurements were then made for blood pressure, mean arterial blood pressure, heart rate and mean product pressure, and side effects were all documented in minute 1, 3 and 5 minutes after intubation. Data analysis was carried out with anova test and chi-square with degree of significance of p < 0,05 and confidence interval of 95%. Results: Group B (fentanyl 1.5 Âμg/kgbw iv administrated 5 minutes before laryngoscopic intubation) was more effective in reducing hemodynamic responses as compared to the other two groups namely group A (fentanyl 1.5 Âμg/kgbb iv administrated 2 minutes before laryngoscopic intubation) and group C (fentanyl 1.5 Âμg/kgbb iv administrated 7 minutes before laryngoscopic intubation). Statistical analysis showed significance of p < 0.05 in minute 1 with mean RPP (p = 032)