KADAR ANGIOTENSIN II PLASMA PADA WANITA DIABETES MELLITUS TIPE 2 DENGAN DAN TANPA HIPERTENSI
| Main Authors: | , Etra Ariadno, , Prof. dr. H.A..H.Asdie, SpPD-KEMD |
|---|---|
| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2011
|
| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/90745/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=52695 |
Daftar Isi:
- Background. Hypertension is a major risk for development and progresivity complication macrovascular and microvascular of diabetes mellitus. Reninangiotensin- aldosteron system (RAAS), insulin resistance, endothelial dysfunction and autonomic nervous dysfunction play an important part in the pathogenesis of hypertension and type 2 diabetes mellitus. In RAAS, increased angiotensin II constricts arterioles, raises total peripheral resistance and blood volume. The rise in intravascular volume increases risk of hypertension. Glucotoxicity or hyperglycemia in type 2 diabetes mellitus can increases angiotensin II levels. Aim. To evaluate plasma angiotensin II levels in type 2 diabetes mellitus women with or without hypertension. Methods. Cross sectional design was conducted on subjects from outpatients women with type 2 diabetes mellitus at endocrinology clinic, Dr. Sardjito General Hospital, Yogyakarta. Hypertension was assessed using criteria from Seventh Joint National Committee (2003). ELISA sandwich�s methods was used to measure plasma angiotensin II levels from veins blood. Differences between groups were compared by student�s unpaired t-test and Mann-Whitney test. Results. Among 60 subjects, there are 30 with hypertension (50%) and 30 without hypertension (50%). Mean age were 54,11 ± 3,36 years old. Plasma angiotensin II levels seemed higher in type 2 diabetes mellitus women with hypertension than without hypertension although they were not statistically significant (0,30 ± 0,15 ng/ml vs. 0,28 ± 0,18 ng/ml, p=0,93). Conclusion. The plasma angiotensin II levels has no significant different between type 2 diabetes mellitus women with or without hypertension.