EFFECT OF ATP BINDING CASETTE SUBFAMILY B MEMBER 1, 5-HYDROXYTRIPTAMINE -3B RECEPTOR AND CYP2D6 GENE POLYMORPHISMS AND SOME RISK FACTORS TO THE ANTIEMETICS RESPONSE THERAPY IN CANCER PATIENTS WITH HIGHLY EMETOGENIC CYTOTOXIC DRUG IN DR. SARDJITO HOSPITAL YOGYAKARTA
| Main Authors: | , Dyah Aryani Perwitasari, M.Si.,Apt., , Prof. dr. M. Hakimi, Ph.D.,Sp.OG(K) |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2011
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/90703/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=52447 |
Daftar Isi:
- Nausea and vomiting are the most distressful side effects of cytotoxic drugs in cancer patients. However, the current antiemetic efficacy is about 70%-80% in patients treated with highly-emetogenic cytotoxic drugs. One of the potential factors explaining this suboptimal response is variability in genes encoding enzymes and proteins which play a role in metabolism, transport and receptors related to antiemetic drugs. Aim of this study was to assess the impact of the variants of ABCB1 drug transporter, 5- HT3B receptors and CYP2D6 genes on antiemetics response to patient with highly emetogenic cytotoxic and the patients� characteristic that influence to response of therapy at Dr. Sardjito Hospital Yogyakarta. This study used prospective non-interventional cohort study. The study population were cancer subjects in the Oncology Department of Dr Sardjito Hospital, Yogyakarta, Indonesia, who were treated with a cisplatin dosage � 50 mg/m 2 as monotherapy or in combinations, ondansetron 8 mg, iv and dexametason 8 mg, iv. The pharmacogenetic assay used subjects saliva as the samples. The severity of nausea were identified by Nausea Visual Analog Scale, while the frequency of vomiting were collected during 24 hours before chemotherapy and 4 x 24 hours after the last dose of cytotoxic drug administration (single or multiple days regimen), by using patients� daily emetogenic record. subjects� quality of life were measured by EORTC QLQ C 3.0, which has been translated and validated into an Indonesian version. subjects were asked to fill in the questionnaires before and 4 x 24 hours after cytotoxic drug administration. Three SNPs of 5-HT3B receptor gene