The Association of -866G/A Polymorphism in UCP2 Gene and -55C/T Polymorphism in UCP3 Gene with Insulin Resistance in Obese Female Adolescents
| Main Authors: | , DIAN EURIKE S, S. KED, , dr. Rina Susilowati, Ph.D. |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2011
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/90557/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=52600 |
Daftar Isi:
- Background Previous study in 2007 reported that 55.7% of 79 obese female adolescents in Yogyakarta were in insulin resistant state. Further study with those 79 obese female adolescents as the studied population showed there were no significant differences on dietary habits and general physical activity between obese female adolescents who were insulin resistant and those who weren�t. Therefore, it was assumed that genetic factors might underlie the difference between both groups. Genetic factors that have been associated with insulin resistance in other populations are -866G/A polymorphism in UCP2 gene and - 55C/T polymorphism in UCP3 gene. Aim To investigate the association of -866G/A polymorphism in UCP2 gene and - 55C/T polymorphism in UCP3 gene with insulin resistance in obese female adolescents in Yogyakarta. Methods A total of 79 obese female adolescents were included in this crosssectional study. Genotyping of -866G/A polymorphism in UCP2 gene and -55C/T polymorphism in UCP3 gene were performed by PCR-RFLP. Results The UCP2 -866A/A homozygous individuals and UCP2 A allele carriers had higher risk for insulin resistance (A/A genotype: OR 2.8