EFEK PROTEIN BISA ULAR TRUNOBAMBAN (Trimeresurus albolabris Gray) TERHADAP ANGIOGENESIS KANKER PAYUDARA TIKUS PUTIH (Rattus norvegicus Berkenhout, 1769)
| Main Authors: | , I Gusti Agung Ayu Ratna Puspitasari, , Dr. Rarastoeti Pratiwi, M.Sc. |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2011
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/90489/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=53131 |
Daftar Isi:
- The venom of Viperidae may contains anti-angiogenesis proteins so that can be used as cancer treatment therapy. Cancer�s growth greatly depends on angiogenesis, the formation of new vessels from the existed vessels of the host toward the cancer tissues. The blockage of angiogenesis process of the cancer�s tissues is cancer therapy alternatives. White-lipped green pit viper is one of the Viperid that abundantly can be found in Indonesia. This study is to know the effect of the snake venom�s protein on breast cancer angiogenesis. In this study, protein fractions of the ammonium sulphate concentration considerably 30% (FP30), 60% (FP60), and 100% (FP100) saturation were used, each has dilution of 50x, 2500x, and 5000x. Antiangiogenesis test was done by using Chorio-Allantoic Membrane (CAM) of chick embryo that were implanted by the normal and breast cancer rat�s graft. Forty-five chicken eggs day 10 were divided into four groups of control and eleven groups of treatments, each had three replications. The study result showed that snake venom�s protein FP60 may inhibit cancer angiogenesis.