EVALUASI DOSIS DIGOKSIN PADA PASIEN GAGAL JANTUNG DENGAN DISFUNGSI GINJAL DI RSUP DR. SARDJITO YOGYAKARTA
| Main Authors: | , Jhonson Parulian Sihombing, , Prof. Dr. Lukman Hakim, M.Sc., Apt. |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2011
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/89539/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=51577 |
Daftar Isi:
- A retrospective and prospective research to evaluate dosage regimen of the digoxin in heart failure patients with renal dysfunction was performed in Dr. Sardjito hospital during January 2010 to March 2011. This work used a descriptive design. Data was conducted by medical record on inpatients where were diagnosed heart failure with renal dysfunction and initiate by digoxin. From 43 cases fulfilling inclusion criteria of the study, it was found that man get bigger percentage compare to women patients (56 % : 44 %). Most patients come from age of 50 � 59 (34.88%), followed by age of 60 � 69 (23.26%), next age of > 70 (18.60 %), then age of 40 � 49 (13.96 %) and the smallest patients come from age of 20 � 29 and 30 � 39 (i.e 4.65 %) Calculation of dose based on pharmacokinetic concept found that some of digoxin dose for patients were exceed digoxin therapeutic concentration. From 19 women patients there were 11 patients use digoxin dose exceed digoxin therapeutic concentration when calculate by pharmacokinetic while from 24 men patients there were 14 patients use digoxin dose exceed digoxin therapeutic concentration when calculate by pharmacokinetic. Dose recalculation method was mostly based on literature data particularly for pharmacokinetic parameter values ie. volume distribution, half life, and clearance. Therefore, the corrected doses suggested in this thesis should be regarded as theoretical estimates. Furthermore, it was also found that patients did not get appropriate loading dose of digoxin. However, drug dosing for digoxin was individual dose, therefore overall found that patient clinical outcome was generally better.