PENINGKATAN PROCALCITONIN SEBAGAI PREDIKTOR KELUARAN KLINIS PADA PENDERITA SEPSIS DI BANGSAL PENYAKIT DALAM RSUP DR SARDJITO YOGYAKARTA
| Main Authors: | , NUNUNG DARTINI WAHYUNINGTYAS, , dr. Kismardhani, SpPK(K), MSc. |
|---|---|
| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2011
|
| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/89357/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=51977 |
Daftar Isi:
- The incidence ofsepsishas atendencyto increase.Report at Dr.Sardjitohospitalalsoshowedan increased prevalenceandmortalitycausedbysepsis, so that a prognostic marker is necessarytopredictthe clinical outcome of patients withsepsis.Procalcitonin(PCT) has beenknownasmarker for bacterial infection and it is importantforassessingseverity ofsepsis. The aim of this study is to know whether increased PCT can be a predictor of clinical outcome in sepsis This study uses a prospective cohort design. Patients entering the Internal ward who meet inclusion and exclusion criterias are examined for the basic data collection. Blood specimen is taken from every patient for the assessment of Sequential Organ Failure Assessment(SOFA)score and examination of PCT on the first day since the diagnosis of sepsis. On the third day since the diagnosis of sepsis, blood specimen is taken again for the assessment of SOFA score and examination of PCT . Patients are observed until the tenth day to determine the assessment of survival analysis. This studyinvolved50subjects who fulfilled inclusion and exclusion criterias. The meanlevels ofPCTondayIandIIIwere 5,19±5,83 ng/mL and 6,37±9,85 ng/mL, respectively. The meanlevels ofPCTondayIandIIIin thegroupwith increased SOFAscorewas5,34±1,74 ng/mL and 8,85±2,22 ng/mL, respectively. The meanlevels ofPCTondayIandIIIin thegroupwithout increased SOFAscore was 5,01±1,17 ng/mL and 3,86±1,46 ng/mL, respectively. The correlation of PCTwith theSOFAscore ondayIandIIIrespectivelywere0,034(p=0,817) and0,754(p =0,001). The increasedPCTpositively correlatedwith theincrease SOFA score(r=0,693