One-pot synthesis of 7-hydroxy-3,4'-dimethoxyisoflavone candidate of drug cancer from 3,4-dimethoxy-phenylacetic acid is derived from eugenol
| Main Authors: | Hairil Alimuddin, Andi, Matsjeh, Sabirin, Anwar, Chairil, Mustofa, Mustofa |
|---|---|
| Format: | Proceeding PeerReviewed application/pdf |
| Bahasa: | eng |
| Terbitan: |
, 2009
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/32894/1/One-pot_synthesis_of_7-hydroxy-3%2C4%27-dimethoxyisoflavone_candidate_of_drug_cancer_from_3%2C4-dimethoxy-phenylacetic_acid_is_derived_from_eugenol.pdf https://repository.ugm.ac.id/32894/ |
Daftar Isi:
- Preparation of 7-hydroxy-3',4'-dimethoxyisoflavone from 3,4-dimethoxy-phenylacetic acid is derived from eugenol by one-pot synthesis method have been done. The acyliation of 3,4-dimethoxy-phenylacetic acid with resorcinol in BF3 etherate as a catalyst and solvent to furnish an intermediate compound 3,4-dimethoxybenzyl-2,4-dihydroxyphenyl ketone which without isolation is subjected to cyclization with N,N-dimethylformamide in the presence of boron trifluoride diethyl etherate and POCI3 to afford the 7-hydroxy-3',4'-dimethoxyisoflavone