Iterleukin-4 and interferon-y in allergic contact dermatitis with atopic background in leather tannery factory worker
| Main Author: | Perpustakaan UGM, i-lib |
|---|---|
| Format: | Article NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2011
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/28442/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=11505 |
Daftar Isi:
- Immune response in allergic contact dermatitis (ACO) patient is dominated by T h.elper-1 (Th-1) response characterized with increase in interferon gamma (lFN-y). However, in atopic individual, the immune response is dominated by T helper-2 (Th-2) response which characterized with the presence of interleukin-4 (IL-4). Based on that condition, it is hypothesized that atopic individual was hardly to develope ACO. In leather factory, many workers are prone to develope ACO. The aim of this study is to differentiate the cytokine profiles of IL-4 and IFN-yof ACO patients with or without atopic background. Using a cross-sectional design, this study involved 30 subject assigned into two groups, one group consisted of 15 subjects with ACO who had atopic background (ACOatopic). the other group consisted of 15 subjects with ACO who had no atopic background (ACOnon atopic). Both groups were examined by patch test and confirmed to have ACO when the result was minimally + 1 in 48 and/or 96 hours examination. Atopic skin diathesis score ~ 8 was used to determine the possibility of having atopic background. Serum IL-4 and IFN-yconcentration were determined using ELISA.Data were analyzed using SPSS with Mann-Whitney non- parametric test. The results showed that the mean value of IL-4 in both groups were 0.18 ::I:0.14 pg/mL and 0.25 ::I:0.29 pg/mL (p =0.917) whereas the mean value of IFN-yin both groups were 13.03 ::I:23.90 pg/mL and 2.76 ::I:5.67 pg/mL, (p =0.096). In conclusion, the cytokine profiles of IL-4 and IFN-y were not significantly different between ACO atopic and ACO non atopic individuals. This finding suggested that atopic and non-atopic individuals had a similar immunologic response during development of ACO.