Perubahan kadar hemoglobin akibat terapi kurkuminoid ekstrak rimpang kunyit dibandingkan natrium diklofenak pada penderita osteoartritis
| Main Author: | Perpustakaan UGM, i-lib |
|---|---|
| Format: | Article NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2011
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/28161/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=11224 |
Daftar Isi:
- ABSTRACT Background: In general, patients with osteoarthritis require long live treatments, especially with anti-inflammatory drugs. Non steroidal anti inflammatory drugs are mostly follow by some side effects such as dyspepsia and gastrointestinal bleeding. The use of natural medicine for rheumatic diseases have commonly been practiced worldwide. Objectives: To learn the changes of hemoglobin level due to treatment with curcuminoid from Curcuma domestica Val. rhizome extract compared to diclofenac sodium as anti-inflammatory agent for the treatment of osteoarthritis. Methods: This research is a prospective randomized open end blinded evaluations (PROBE). Patients treated with 30 mg curcuminoid from Curcuma domestica Val. rhizome extract or 25 mg diclofenac sodium three times daily for 4 weeks respectively.The hemoglobin level was checked before and after treatment. Results: A total of 80 patients with knee osteoarthritis participated in this study. There was no significant difference in sex, educational level, duration of disease suffering, percentage of co-morbidities in both groups. There was no significant different of hemoglobin level before treatment between both treatment group. The hemoglobin level was increase significantly in curcuminoid treatment groups while no significant change in diclofenac group. Treatment with curcuminoid increasing the hemoglobin level significantly compare to diclofenac sodium (p=0.03). Conclusion: Treatment with curcuminoid from Curcuma domestica Val. rhizome increase the hemoglobin level significantly compared to diclofenac sodium treatment for osteoarthritis. KEY WORDS change of hemoglobin concentration, curcuminoid, diclofenac sodium, osteoarthritis