Peranan Toll-Like Receptors terhadap Terjadinya Meningitis Thberkulosis
| Main Author: | Perpustakaan UGM, i-lib |
|---|---|
| Format: | Article NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2009
|
| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/27771/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=10834 |
Daftar Isi:
- Tuberculousmeningitis (TBM) is the severestform of infection with Mycobacterium tuberculosis, causing death or severe neurologic deficits in more than half of those ajj( cted in spite of antituberculosis chemotherapy.Incidence of TBM is about 5'Y()-IO%fromall population of people which infected with tuberculosis. Whysome people develop clinical disease remains unclear. The reasons are likely to be multifactorial: inherent not just to the individual person, but to their given population and environment. TBM results from the haematogenous dissemination of Mycobacterium tuberculosisfrom the lung to the brain. Dissemination is believed to occur early during infection, before the development of adaptive immunity. The pathogenesis of tuberculous meningitis remains unclear, and there arefew data describing the kinetics of the immune response during thl[!course of its treatment. Toll-likereceptors (TLRs)play an important role in innate immunity to invadingpathogens by sensing microorganisms. A number of reports have recentlyfound mutations al'ldpolymorphisms in Toll-likereceptor (TLR)genes that affect host susceptibility to infectious diseases include TBM TLR2single nucleotidepolymorphisms (SNP) T597C and TIRAPSNP C558T are strong association with the susceptibility to development ofTBM SNP may result in an attenuatedearly innateimmuneresponseto infectionwithM tuberculosis,a heavierandmoreprolonged bacillaemia, and a greater chance of developing TBM