Correlation of interleukin-6 and monocyte count to troponin I in acute coronary syndrome
| Main Author: | Perpustakaan UGM, i-lib |
|---|---|
| Format: | Article NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2008
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/27518/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=10578 |
Daftar Isi:
- Background: Acute coronary syndrome (ACS) becomes an important disease, because of its increased prevalence and mortality rates. Makers of systemic inflammation, including interleukin-6 and monocyte count, have been shown to predict future cardiovascular events. However, the association between these inflammatory markers with cardiac injury is still a controversy. Objective: To evaluate the relationship between IL-6 and monocyte count as inflammation markers and troponin I as cardiac injury. Methods: This was a cross-sectional study. Subjects were patients suspected of ACS admitted to the emergency department of Sardjito Hospital Yogyakarta. Diagnoses were performed based on WHO criteria. Troponin I and interleukin-6 levels were measured from sera using sandwich ELISA method (Roche). Monocyte counts were determined by automatic hematology analyzer (Sysmex). Kruskal-Wallis test and Spearman's correlation test were used to assess the difference and correlation between parameters. Results: Sixty one (61) subjects were included in the study. Age of the subjects were 51-60 years, and diagnosed as ST elevation myocardial infarct (STEMI). Significant differences of IL-6 and troponin I levels were determined among unstable angina pectoris (UAP), non-ST elevation myocardial infarct (NSTEMI), and ST elevation myocardial infarct (STEMI) subjects. There was a moderate correlation (r = 0.54