Immobilization of Bombyx Mori's Sericin on Poly (L-Latic Acid) Films and its Effect on Surface Hydrophilicity
| Main Authors: | Yustisia, Yenny, Sunarintyas, Siti, Susilowati, Rina |
|---|---|
| Format: | Proceeding PeerReviewed application/pdf |
| Bahasa: | eng |
| Terbitan: |
, 2012
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/273539/1/34.pdf https://repository.ugm.ac.id/273539/ |
Daftar Isi:
- Poly(L-lactic acid) or PLLA as one of tissue engineering material have demonstratedlow cell interaction capability due to its hydrophobicity. Bombyx mori’s sericin, a natural polymer protein, contains large amount of polar functional group which has hydrophilic characteristic. The aim of this study was to modified PLLA surface using Bombyx mori’s sericin and to investigate its effect on surface hydrophilicity. Three concentrations of sericin (2.5, 5, and 10mg/mL) were applied on PLLA surfaceusing carbodiimide chemistry. Surface characterization using Fourier Transform-Infrared Spectroscopy (FTIR) was performed to observe the changes on surface-modified PLLA. The evaluation of surface hydrophilicity was made through water contact angle measurements. FTIR graphs showed that new absorbtion bands located at 1597 cm-1 has appear assigned to the amide bond (N-H) which indicates that sericin was successfully immobilized to PLLA surface by carbodiimide chemistry. The contact angle of PLLA surface was measured to be ±78.38o and decreases to about 42o after modified with sericin. The conclusion was PLLA surface can be modified with Bombyx mori’s sericin and surface hydrophilicity was enhanced.